直肠粘液T抗原检测用于大肠癌筛检  

Screening of Colorectal Cancer by Testing T-antigen in the Rectal Mucus

作　　者：陈宗祐[1] 邓景德[1] 王德昭[1] 孙鹏[1] 辛国明[1] 吕元[2] 

机构地区：[1]上海医科大学华山医院外科,200040 [2]上海医科大学华山医院检验科,200040

出　　处：《外科》1996年第4期164-166,共3页

摘　　要：应用花生凝集素对150例指检获取的直肠粘液进行T抗原检测,在70例大肠癌中阳性者36例(51.4％),在30例大肠息肉中阳性者8例(26.7％),而50例大肠粘膜正常者仅3例阳性(6％)。本组资料表明,该法对大肠癌检出的敏感性为51.4％,特异性为94％,阳性预测值为76.6％,而且该试验简便快速,可望用于大肠癌的筛检。Peanut agglutinin (PNA) was employed to detect T-antigen presented in rectal mucus of 150 cases obtained by digital rectal examination. Positive response was observed in 36 of 70 patients (51.4%) with colorectal cancer and 8 of 30 patients (26.7%) with colorectal polyp, only 3 showed positive response (6%) in 50 normal subjects. The results suggested the sensitivity to cancer was 51.4%, specificity, 94% and predictive value of positive test, 76.6%. The test will be useful for mass screening of colorectal cancer because it is simple, rapid and technically convenient.

关 键 词：大肠癌 T抗原 花生凝集素 筛检 

分 类 号：R735.340.4[医药卫生—肿瘤]