细胞角蛋白-19基因在甲状腺癌中的表达及意义  

Expression of cytokeratin-19 gene and its significance in thyroid carcinoma

作　　者：杨燕初[1] 陆竞艳[2] 卓建红[1] 史琳[1] 任传伟[1] 

机构地区：[1]柳州医学高等专科学校,广西柳州545006 [2]广西医科大学

出　　处：《山东医药》2007年第9期20-21,共2页Shandong Medical Journal

基　　金：广西医疗卫生重点科研项目(Z2005202)

摘　　要：目的探讨细胞角蛋白-19(CK-19)mRNA在甲状腺癌中的表达及其意义。方法用RT-PCR方法检测甲状腺癌(27例)、良性甲状腺疾病(18例)及正常甲状腺(9例)组织中CK-19 mRNA的表达。结果CK-19 mRNA在甲状腺癌组中表达为2.63±2.14,与非癌组相比,P<0.05;在有淋巴转移的甲状腺癌组的表达为3.41±2.63,明显高于无转移者的1.79±0.97,P<0.05。结论CK-19 mRNA在甲状腺癌组织中表达明显增强,且与淋巴结转移有关,提示CK-19可能参与了甲状腺癌的发生发展,并对肿瘤转移有促进作用。[Objective] To detect expression and mechanism of cytokeratin-19 （CK-19） mRNA in the genesis of thyroid carcinoma. [Methods] Expressions of CK-19 mRNA in fresh freezing tissues were detected by RT- PCR in 27 cases of thyroid carcinomas, 18 benign thyroid diseases and 9 normal thyroid tissues. [Results] There was significant difference in the expression of CK-19 between the carcinomas and benign lesions concerning. The CK-19 mRNA expression in the thyroid cancers with lymphnode metastasis was higher than that in the thyroid cancers without lymphnode metastasis （ P〈0.05）. [Conclusion] The expression of CK-19 mRNA inereases in thyroid cancers,and relate with cell differentiation and metastasis. The abnormal expression of CK-19 probably participates in genesis and development of thyroid cancers.

关 键 词：甲状腺肿瘤 细胞角蛋白-19 逆转录聚核酶联反应 

分 类 号：R736.1[医药卫生—肿瘤]