瘦素、肿瘤坏死因子-α与代谢综合征关系  

Effects of leptin and TNF-α on metabolic syndrome

作　　者：赵晓雯[1] 乔虹[2] 刘艳[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,哈尔滨150081 [2]哈尔滨医科大学附属第二医院

出　　处：《中国公共卫生》2007年第4期437-439,共3页Chinese Journal of Public Health

基　　金：黑龙江省自然科学基金项目(D2005-55);黑龙江省卫生厅项目(2005-004);黑龙江省教育厅项目(11513052)

摘　　要：目的探讨脂肪细胞因子瘦素、肿瘤坏死因子-α在代谢综合征发病机制中的作用。方法检测社区人群瘦素和肿瘤坏死因子-α的血浆水平,采用Logistic回归分析,经过对年龄和性别的调整,研究瘦素、肿瘤坏死因子-α与代谢综合征的关系。结果瘦素水平愈高发生代谢综合征的危险性愈大,瘦素与代谢综合征的关系受性别与年龄的影响,男性比女性对瘦素水平变化更为敏感,随年龄增长瘦素对代谢综合征发生的危险增大。肿瘤坏死因子-α水平愈低发生代谢综合征的危险性愈大,其高水平的患病危险性是低水平的0.538倍。结论高瘦素性肥胖对代谢综合征的影响男性表现得更为明显,瘦素水平可以作为预测代谢综合征的指标,尤其在老年男性中更为有效。Objective To discover the effects of the leptin and TNF-α （tumor necrosis factor-alpha） in the cause of metabolic syndrome. Methods The research includes testing on the level of leptin and TNF-α in the blood of residents of a local community, analyzing the cause of metabolic syndrome in relation to leptin and TNF-α through Logistic regression analysis by adjusting age and gender. Results The higher the leptin levels were, the higher risk metabolic syndrome was. The relationship between leptin levels and metabolic syndrome was affected by age and gender. Males were more sensitive to leptin than females. The effect of leptin on metabolic syndrome increased with the age. The lower the level of TNF-α was, the higher risk metabolic syndrome was. The chances for residents with higher level of TNF-α to suffer from disease was 0. 538 times of thos with lower level. Conclusion Obesity with high level leptin affects metabolic syndrome, especially males obsity. Leptin level can be used as an indicator in predicting metabolic syndrome. This method is especially effective to old male patients. It is necessary to do further research on thd biological mechanism of metabolic syndrome.

关 键 词：瘦素 肿瘤坏死因子-Α 胰岛素抵抗 代谢综合征 

分 类 号：R181.38[医药卫生—流行病学]