乳头状肾细胞癌的临床病理研究  

Clinicopathologic Study of Papillary Renal Cell Carcinoma

作　　者：周瑞锦[1] 宋少康[1] 姬彤宇[1] 

机构地区：[1]河南省人民医院泌尿外科,郑州市450003

出　　处：《医药论坛杂志》2007年第2期11-12,共2页Journal of Medical Forum

摘　　要：目的 探讨乳头状肾细胞癌的临床病理特征，提高对乳头状肾细胞癌的诊断及治疗水平。方法 回顾总结了25例乳头状肾细胞癌患者的诊断、治疗及随访情况。结果25例乳头状肾细胞癌占同期肾癌的13．5％，平均发病年龄52．3岁。肿瘤最大径2～15cm，均以乳头或乳头管状结构为主，乳头轴心可见泡沫细胞。均有细胞角蛋白CK7表达。病理分型I型肿瘤15例，Ⅱ型肿瘤10例。病理分级高分化14例、中分化7例，低分化4例。随访6—60个月，2例分别于术后8、15个月死于转移，其余均生存。结论 乳头状肾细胞癌具有特殊的临床病理特征，其分型和分级、分期有关，其确诊有赖于典型病理检查，治疗仍以手术为主。Objective To investgate the clinicopathological characteristics of papillary renal cell carcinoma（PRCC） for improving its diagnosis and treatment. Methods The status of diagnosis, treatment and follow - up of 25 cases of papillary renal cell carcinoma were retrospectively analyzed. Results 25 （ 13.5% ） cases PRCC were identified. The mean age is 52. 3 years. The tumor ranged from 2 to 15cm. All were predominantly papillary or tubulopaillary often with foam cells. Cytokeratin 7 was expressed in all cases. 15 cases were type Ⅰ and 10 cases type Ⅱ. The Fuhnnan＇s nuclear grade of the PRCC was well - differentiated in 14 csses, moderately differentiated in 7 cases and poor - differentiated in 4 cases. Follow - up of 6 to 60 months demonstrated that 2 patients died of tumor metastasis at 8 and 15 months after operation, respectively, while others survived without tumor. Conclusion PRCC has a distinct clinicopathological characteristics. The pathologic type is correlated with grade and stage. Definite diagnosis depends on the typical pathological features. The surgical therapy is main process of treatment.

关 键 词：肾肿瘤 乳头状腺癌 诊断 病理学 

分 类 号：R737.11[医药卫生—肿瘤]