CdS Quantum Dots as Fluorescence Probes for Detection of Adriamycin Hydrochloride  

作　　者：LIAO Qie-gen LI Yuan-fang HUANG Cheng-zhi 

机构地区：[1]College of Chemistry and Chemical Engineering, Southwest University,Chongqing 400715, P. R. China

出　　处：《Chemical Research in Chinese Universities》2007年第2期138-142,共5页高等学校化学研究（英文版）

基　　金：the National Natural Science Foundation of China(No 30570465) ;the Municipal Science and Technology Committee of Chongqing

摘　　要：Water-soluble CdS quantum dots（CdS-QDs） capped with thioglycohc acid were easily prepared, and a detection method of adriamycin was presented based on the fluorescence quenching of CdS-QDs. It was found that a complex could be formed between cetyhrimethyl ammonium bromide（CTAB） and CdS-QDs by using electrostatic interaction in Britton-Robinson（BR） buffer at pH = 7.00, and the strong fluorescence emission of the complex was observed at 500 nm when the complex was excited at 378 run. The presence of adriamycin, however, could strongly quench the fluorescence through hydrophobic interaction. The overall quenching percentage as a function of adriamycin concentration matches the Stern-Volmer equation very well. These properties make CdS-QDs a potential fluorescence probe for the detection of adriamycin. The detection hmit（3σ） of adriamycin is approximately 10^-9 mol/L.Water-soluble CdS quantum dots（CdS-QDs） capped with thioglycohc acid were easily prepared, and a detection method of adriamycin was presented based on the fluorescence quenching of CdS-QDs. It was found that a complex could be formed between cetyhrimethyl ammonium bromide（CTAB） and CdS-QDs by using electrostatic interaction in Britton-Robinson（BR） buffer at pH = 7.00, and the strong fluorescence emission of the complex was observed at 500 nm when the complex was excited at 378 run. The presence of adriamycin, however, could strongly quench the fluorescence through hydrophobic interaction. The overall quenching percentage as a function of adriamycin concentration matches the Stern-Volmer equation very well. These properties make CdS-QDs a potential fluorescence probe for the detection of adriamycin. The detection hmit（3σ） of adriamycin is approximately 10^-9 mol/L.

关 键 词：Fluorescence quenching CdS quantum dots ADRIAMYCIN 

分 类 号：R979.14[医药卫生—药品] O657.31[医药卫生—药学]