This study aimed to investigate the impact of administration routes in establishing the Adriamycin(ADR)-induced chronic kidney disease(CKD)model.Using BALB/c mice,we compared the effects of conventional tail-vein inje...
funded by the National Natural Science Foundation of China(No.81972478);the Fundamental Research Funds for the Central Universities(China)(No.2242020K40131);the Jiangsu Provincial Key Laboratory of Critical Care Medicine(China)(No.JSKLCCM-2022-02-013).
Adriamycin(ADR),also known as doxorubicin,is an anthracycline anticancer drug and a chemotherapeutic drug commonly used in breast cancer treatments.1 However,breast cancer patients can gradually become tolerant to che...
supported by the National Natural Science Foundation of China(Nos.82172048 and U21A20378);Scientific Research Project of Shanxi Provincial Health Commission(No.2023120);Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(No.2021SX-FR010);Shanxi Center of Technology Innovation for Controlled and Sustained Release of Nanodrugs(No.202104010911026);Foundational Research Project of Shanxi Province(No.202203021211159);Four“Batches”Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(No.2023XM012);Shanxi Scholarship Council of China(No.2022–039)。
Carbon dots(CDs)with precise targeting function show great potential in the field of drug delivery therapeutics.In this study,the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence...
the National Key Research and Development Project(Nos.2019YFC1708802 and 2017YFC1702800);Henan province high-level personnel special support“ZhongYuan One Thousand People Pla”,Zhongyuan Leading Talent(No.ZYQR201810080);the Major Science and Technology Projects in Henan Province:Study on the key technology for quality control and the key characteristics of Rehmannia glutinosa,Dioscorea opposita Thunb.and Achyranthes bidentata Blume from Henan Province(No.171100310500).
This study aimed to investigate the effect and mechanisms of Ephedra Herb(EH)extract on adriamycin-induced nephrotic syndrome(NS),providing an experimental basis for the clinical treatment of NS.Hematoxylin and eosin ...
the National Natural Science Foundation of China(Grant nos:81973322,81902706);Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,the Fundamental Research Funds for the Central Universities(Grant nos:JUSRP221037,JUSRP22007,JUSRP122055);Jiangsu Province"Six Summit Talents"Program(Grant no:YY-038);Wuxi Taihu Talent Project.
Long-term treatment with adriamycin(ADR)is associated with higher incidences of cumulative cardiotoxicity manifest as heart failure.ADR-induced cardiomyopathy is characterized by extensive fibrosis that is caused by c...
Objective To analyze the inhibitory effect and mechanism of glycyrrhizic acid preparation on adriamycin(ADM)-induced heart and liver injury in mice.Methods A total of 60 mice were selected and randomly divided into no...
National Natural Science Foundation Project(No.81573720,81974536)。
Objective:To determine the therapeutic effect of Danggui Shaoyao San with Huangqi on rats with nephrotic syndrome(NS)was discussed,and the scientific connotation of TCM treatment principle was elaborated,so as to prov...
supported by a grant from the Deputy of Research and Technology Development of Ahvaz Jundishapur University of Medical Sciences(Grant No.97s55)
Objective:To evaluate the effect of p-coumaric acid against adriamycin-induced hepatotoxicity in rats.Methods:The rats were divided into 4 groups.The control group received solvent;the p-coumaric acid group was treate...
The National Natural Science Foundation of China(Grant No.81660130);the Natural Science Foundation of Gansu Province,China(Grant No.18JR3RA045).
The Chinese medicine Extractum trametes robiniophila murr(ETRM)is the extract of a type of fungus.Recent studies have suggested that ETRM efficiently improves the effacement of podocyte foot processes in adriamycin(AD...
Supported by the Science and Technology Program of Liaoning Province(No.2009225034);Research of Parthenolide Inhibit Gastric Cancer and Increase Chemotherapy Sensitivity。
OBJECTIVE:To investigate the effect of parthenolide(PTL),a sesquiterpene lactone medicinal compound,on the sensitivity of the gastric cancer cell line SGC7901 and the DPP-and ADR-resistant sublines SGC7901/DDP and SGC...