ADRIAMYCIN

作品数:126被引量:324H指数:10
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相关领域:医药卫生更多>>
相关作者:周虹彭波曹建国唐小卿郭伟剑更多>>
相关机构:苏州大学复旦大学南华大学复旦大学附属肿瘤医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划天津市自然科学基金更多>>
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Effectively simplified Adriamycin-induced chronic kidney disease mouse model:Retro-orbital vein injection versus tail-vein injection
《Animal Models and Experimental Medicine》2025年第3期568-572,共5页Masaki Watanabe Hayato R.Takimoto Kazuki Hashimoto Yuki Ishii Nobuya Sasaki 
This study aimed to investigate the impact of administration routes in establishing the Adriamycin(ADR)-induced chronic kidney disease(CKD)model.Using BALB/c mice,we compared the effects of conventional tail-vein inje...
关键词:Adriamycin nephropathy BALB/c CKD orbital vein injection tail-vein injection 
LncRNA HCP5-encoded protein contributes to adriamycin resistance through ERK/mTOR pathway-mediated autophagy in breast cancer cells被引量:1
《Genes & Diseases》2024年第4期69-72,共4页Jia-Ni Xing Yi-Ni Shang Zheng-Ling Yu Shun-Heng Zhou Wang-Yang Chen Li-Hong Wang 
funded by the National Natural Science Foundation of China(No.81972478);the Fundamental Research Funds for the Central Universities(China)(No.2242020K40131);the Jiangsu Provincial Key Laboratory of Critical Care Medicine(China)(No.JSKLCCM-2022-02-013).
Adriamycin(ADR),also known as doxorubicin,is an anthracycline anticancer drug and a chemotherapeutic drug commonly used in breast cancer treatments.1 However,breast cancer patients can gradually become tolerant to che...
关键词:BREAST cancer HOMEOSTASIS 
Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy
《Chinese Chemical Letters》2024年第6期421-426,共6页Qiang Li Jiangbo Fan Hongkai Mu Lin Chen Yongzhen Yang Shiping Yu 
supported by the National Natural Science Foundation of China(Nos.82172048 and U21A20378);Scientific Research Project of Shanxi Provincial Health Commission(No.2023120);Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(No.2021SX-FR010);Shanxi Center of Technology Innovation for Controlled and Sustained Release of Nanodrugs(No.202104010911026);Foundational Research Project of Shanxi Province(No.202203021211159);Four“Batches”Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(No.2023XM012);Shanxi Scholarship Council of China(No.2022–039)。
Carbon dots(CDs)with precise targeting function show great potential in the field of drug delivery therapeutics.In this study,the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence...
关键词:Carbon dots Nucleus-targeting ADRIAMYCIN Drug delivery system Liver cancer therapy 
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway被引量:3
《Chinese Journal of Natural Medicines》2023年第5期371-382,共12页ZHANG Yuhan ZENG Mengnan LI Benke ZHANG Beibei CAO Bing WU Yuanyuan YE Shan XU Ruiqi ZHENG Xiaoke FENG Weisheng 
the National Key Research and Development Project(Nos.2019YFC1708802 and 2017YFC1702800);Henan province high-level personnel special support“ZhongYuan One Thousand People Pla”,Zhongyuan Leading Talent(No.ZYQR201810080);the Major Science and Technology Projects in Henan Province:Study on the key technology for quality control and the key characteristics of Rehmannia glutinosa,Dioscorea opposita Thunb.and Achyranthes bidentata Blume from Henan Province(No.171100310500).
This study aimed to investigate the effect and mechanisms of Ephedra Herb(EH)extract on adriamycin-induced nephrotic syndrome(NS),providing an experimental basis for the clinical treatment of NS.Hematoxylin and eosin ...
关键词:Ephedra Herb Methylephedrine ADRIAMYCIN Nephrotic syndrome CAMKK2/AMPK/mTOR pathway 
Adriamycin induces cardiac fibrosis in mice via PRMT5-mediated cardiac fibroblast activation被引量:2
《Acta Pharmacologica Sinica》2023年第3期573-583,共11页Xiao-liang Dong Bao-hui Yuan Sheng-zhou Yu He Liu Xiao-hua Pan Jia Sun Li-long Pan 
the National Natural Science Foundation of China(Grant nos:81973322,81902706);Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,the Fundamental Research Funds for the Central Universities(Grant nos:JUSRP221037,JUSRP22007,JUSRP122055);Jiangsu Province"Six Summit Talents"Program(Grant no:YY-038);Wuxi Taihu Talent Project.
Long-term treatment with adriamycin(ADR)is associated with higher incidences of cumulative cardiotoxicity manifest as heart failure.ADR-induced cardiomyopathy is characterized by extensive fibrosis that is caused by c...
关键词:ADRIAMYCIN CARDIOTOXICITY cardiac fibrosis cardiac fibroblasts protein arginine methyltransferase 5 transforming growth factor-β1 
Inhibitory effect of glycyrrhizic acid preparation on cardiac and liver injury induced by adriamycin in mice
《China Medical Abstracts(Internal Medicine)》2021年第3期139-139,共1页WU Yongchao 
Objective To analyze the inhibitory effect and mechanism of glycyrrhizic acid preparation on adriamycin(ADM)-induced heart and liver injury in mice.Methods A total of 60 mice were selected and randomly divided into no...
关键词:ADRIAMYCIN PREPARATION LIVER 
Effect of Danggui Shaoyao San with Huangqi on adriamycin-induced nephrotic syndrome in rats
《Journal of Hainan Medical University》2021年第9期20-25,共6页Sheng-Nan Fan Mei-Feng Ou Yun-Lai Wang Mo Yang Zi-Hua Xuan Fan Xu 
National Natural Science Foundation Project(No.81573720,81974536)。
Objective:To determine the therapeutic effect of Danggui Shaoyao San with Huangqi on rats with nephrotic syndrome(NS)was discussed,and the scientific connotation of TCM treatment principle was elaborated,so as to prov...
关键词:Invigorating Qi as well as promoting blood and water circulation Nephrotic syndrome Danggui Shaoyao San Huangqi RATS 
p-Coumaric acid alleviates adriamycin-induced hepatotoxicity in rats
《Asian Pacific Journal of Tropical Biomedicine》2021年第3期115-121,共7页Zeinab Rafiee Maasoumeh Zare Moaiedi Armita Valizadeh Gorji Esrafil Mansouri 
supported by a grant from the Deputy of Research and Technology Development of Ahvaz Jundishapur University of Medical Sciences(Grant No.97s55)
Objective:To evaluate the effect of p-coumaric acid against adriamycin-induced hepatotoxicity in rats.Methods:The rats were divided into 4 groups.The control group received solvent;the p-coumaric acid group was treate...
关键词:ADRIAMYCIN HEPATOTOXICITY p-Coumaric acid ANTIOXIDANT IL-1Β 
Extractum trametes robiniophila murr protects murine podocyte via actin cytoskeleton stabilization被引量:1
《Journal of Chinese Pharmaceutical Sciences》2021年第3期230-238,共9页Xuan Luo Qing Du Haiyan Zhao Wenhai Fan Xin Gao Xia Gao 
The National Natural Science Foundation of China(Grant No.81660130);the Natural Science Foundation of Gansu Province,China(Grant No.18JR3RA045).
The Chinese medicine Extractum trametes robiniophila murr(ETRM)is the extract of a type of fungus.Recent studies have suggested that ETRM efficiently improves the effacement of podocyte foot processes in adriamycin(AD...
关键词:Actin rearrangements Extractum trametes robiniophila murr Foot processes ADRIAMYCIN 
Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy被引量:5
《Journal of Traditional Chinese Medicine》2020年第6期908-916,共9页Liu Minghua Yang Ying Liu Dajun Cao Ye Li Yan 
Supported by the Science and Technology Program of Liaoning Province(No.2009225034);Research of Parthenolide Inhibit Gastric Cancer and Increase Chemotherapy Sensitivity。
OBJECTIVE:To investigate the effect of parthenolide(PTL),a sesquiterpene lactone medicinal compound,on the sensitivity of the gastric cancer cell line SGC7901 and the DPP-and ADR-resistant sublines SGC7901/DDP and SGC...
关键词:PARTHENOLIDE CISPLATIN ADRIAMYCIN Gastric cancer CHEMOTHERAPY Sensitivity 
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