Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy  

作　　者：Qiang Li Jiangbo Fan Hongkai Mu Lin Chen Yongzhen Yang Shiping Yu 

机构地区：[1]The Second Hospital of Shanxi Medical University,Taiyuan 030001,China [2]Shanxi Medical University,Taiyuan 030001,China [3]Key Laboratory of Interface Science and Engineering in Advanced Materials,Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,China [4]Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030032,China

出　　处：《Chinese Chemical Letters》2024年第6期421-426,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82172048 and U21A20378);Scientific Research Project of Shanxi Provincial Health Commission(No.2023120);Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(No.2021SX-FR010);Shanxi Center of Technology Innovation for Controlled and Sustained Release of Nanodrugs(No.202104010911026);Foundational Research Project of Shanxi Province(No.202203021211159);Four“Batches”Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(No.2023XM012);Shanxi Scholarship Council of China(No.2022–039)。

摘　　要：Carbon dots(CDs)with precise targeting function show great potential in the field of drug delivery therapeutics.In this study,the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence(NLS)were loaded with adriamycin(DOX)to obtain a nucleus-targeting orange-emissive CDs drug delivery system(CDs-NLS-DOX),which delivered DOX to tumor cell nuclei to enhance its anti-tumor activity.The drug carrier orange-emissive CDs showed excitation-independent behavior,stable and enhanced imaging capability and good biocompatibility in vitro and in vivo.Meanwhile,the CDs-NLS could target the nuclei efficiently,and the CDs-NLS-DOX complexes had a high drug loading rate(59.4%)after loading DOX,exhibiting p H-dependent DOX release behavior through breaking acylhydrazone bond in a weak acidic environment.In addition,the CDs-NLS-DOX complexes exhibited an enhanced killing activity against human hepatoma cells(HepG2).The in vivo therapeutic effects on HepG2 nude mice transplanted tumors indicated the CDs-NLS-DOX had a stronger ability to inhibit tumor growth compared to free DOX.In short,CDs-NLS-DOX is expected to be a precise and efficient nucleus-targeting nano-drug delivery system for tumor treatment.

关 键 词：Carbon dots Nucleus-targeting ADRIAMYCIN Drug delivery system Liver cancer therapy 

分 类 号：TQ460.1[化学工程—制药化工] TQ127.11[医药卫生—肿瘤] R735.7[医药卫生—临床医学]