PARTHENOLIDE

作品数：27被引量：85H指数：5
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相关领域：医药卫生更多>>
相关作者：李涛王磊雷志年曾水林朱建宝更多>>
相关机构：郑州大学东南大学中山大学南方医科大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Journal of Biomedical Research》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金北京市自然科学基金江苏省自然科学基金天津市自然科学基金更多>>
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核因子κB抑制剂parthenolide联合柔红霉素对髓系白血病小鼠的治疗效应
《郑州大学学报(医学版)》2025年第2期290-293,共4页胡国敏 赵杨 符雪如 吴钰莹 卢洁 张红艳 
目的:探讨核因子κB(NF-κB)抑制剂parthenolide(PN)联合柔红霉素(DNR)对髓系白血病小鼠的治疗效应。方法:20只Nu/Nu裸鼠通过接种急性单核细胞白血病细胞株THP-1构建移植瘤模型后,采用随机数字表法分为空白对照组、PN组、DNR组和PN+DNR...
关键词：髓系白血病 核因子κB PARTHENOLIDE 柔红霉素 裸鼠 移植瘤 
Parthenolide enhances the metronomic chemotherapy effect of cyclophosphamide in lung cancer by inhibiting the NF-kB signaling pathway
《World Journal of Clinical Oncology》2024年第7期895-907,共13页Zheng Cai Lang Gao Kai Hu Qi-Ming Wang 
Supported by Joint Funding of Yunnan Ministry of Science and Technology,No.2019FF002-048;and Beijing Heathco Clinical Oncology Research Foundation,No.Y-Q201802-048.
BACKGROUND Parthenolide(PTL),a sesquiterpene lactone derived from the medicinal herb Chrysanthemum parthenium,exhibits various biological effects by targeting NF-kB,STAT3,and other pathways.It has emerged as a promisi...
关键词：Lung cancer PARTHENOLIDE CYCLOPHOSPHAMIDE Rhythmic chemotherapy NF-κB pathway 
Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics被引量：3
《Acta Pharmacologica Sinica》2023年第8期1701-1711,共11页Wen-si Zhao Kai-feng Chen Man Liu Xing-long Jia Yu-qi Huang Bing-bing Hao Hao Hu Xiao-yan Shen Qiang Yu Min-jia Tan 
supported by the National Key R&D Program of China (2020YFE0202200);the National Natural Science Foundation of China (32071432,21907100,22225702);the Program of Shanghai Academic Research Leader (22XD1420900);the Science and Technology Commission of Shanghai Municipality (19JC1416300);the Natural Science Foundation of China for Innovation Research Group (81821005);the Shanghai Sailing Program (21YF1456000);the open fund of state key laboratory of Pharmaceutical Biotechnology,Nanjing University,China (KF-202201);the National Key R&D Program of China (2018YFC1705500).
Eriocalyxin B(EB),17-hydroxy-jolkinolide B(HJB),parthenolide(PN),xanthatin(XT)and andrographolide(AG)are terpenoid natural products with a variety of promising antitumor activities,which commonly bear electrophilic gr...
关键词：natural products PROTEOMICS ABPP eriocalyxin B PARTHENOLIDE 
Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents被引量：5
《Chinese Journal of Natural Medicines》2022年第11期814-829,共16页LIU Xingchen WANG Xiaobing 
supported by the Natural Science Foundation of Jiangsu Province(No.BK20201332);the“Double First-Class”University Project(No.CPU2018GF03);the Six Talent Peaks Project of Jiangsu Province(No.SWYY-107);Jiangsu Province‘333’Project,111 Center from Ministry of Education of China and the State Administration of Foreign Experts Affairs of China(No.B18056).
Parthenolide(PTL)is a sesquiterpene lactone derived from medicinal plant feverfew(Tanacetum parthenium).Recent studies have demonstrated that it has multiple pharmacological activities,especially in the treatment of v...
关键词：PARTHENOLIDE DERIVATIVES Structural modification Anticancer mechanisms 
Parthenolide reveals an allosteric mode to inhibit the delSGylation activity of SARS-CoV-2 papain-like protease
《Acta Biochimica et Biophysica Sinica》2022年第8期1133-1139,共7页Zhihui Zou Huizhuang Shan Demeng Sun Li Xia Yulong Shi Jiahui Wan Aiwu Zhou Yunzhao Wu Hanzhang Xu Hu Lei Zhijian Xu Yingli Wu 
This work was supported in part by the grants from the National Key Research and Development Program of China(No.2017YFA0505200);Science and Technology Committee of Shanghai(Nos.19ZR1428700,and 20ZR1430600);the National Natural Science Foundation of China(Nos.82170145,81700157,and 81700475);Innovative research team of high-level local universities in Shanghai(No.SHSMU-ZDCX20211802).
The coronavirus papain-like protease(PLpro)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for viral polypeptide cleavage and the deISGylation of interferon-stimulated gene 15(ISG15),which...
关键词：COVID-19 SARS-CoV-2 PLpro PARTHENOLIDE deISGylation 
Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy被引量：5
《Journal of Traditional Chinese Medicine》2020年第6期908-916,共9页Liu Minghua Yang Ying Liu Dajun Cao Ye Li Yan 
Supported by the Science and Technology Program of Liaoning Province(No.2009225034);Research of Parthenolide Inhibit Gastric Cancer and Increase Chemotherapy Sensitivity。
OBJECTIVE:To investigate the effect of parthenolide(PTL),a sesquiterpene lactone medicinal compound,on the sensitivity of the gastric cancer cell line SGC7901 and the DPP-and ADR-resistant sublines SGC7901/DDP and SGC...
关键词：PARTHENOLIDE CISPLATIN ADRIAMYCIN Gastric cancer CHEMOTHERAPY Sensitivity 
The Antitumor Activity and Mechanism of MCL3 in G422 Glioblastoma被引量：1
《World Journal of Traditional Chinese Medicine》2020年第3期353-361,共9页Qian-Qian Du Mei Tang Lu-Lu Huang Ru Zhao Chen Yan Yan Li Xian-Dao Pan 
supported by the Chinese Academy of Medical Sciences(CAMS)Initiation fund for Medical Science(2016-I2M-1-008);the Drug Innovation Major Project(2018ZX09711-001-005)。
Objective:Parthenolide(PTL)induces anti-tumor effects via the nuclear factor kappa B(NF-κB)signaling pathway.MCL3,a PTL derivative,is a sesquiterpene lactone synthesized by the rearrangement and subsequent oxidation ...
关键词：GLIOBLASTOMA MCL3 nuclear factor kappa B/interleukin-6/Stat3 parthenolide derivative 
NF-kB Inhibitor Parthenolide Promotes Renal Tubules Albumin Uptake in Type 2 Diabetic Nephropathy被引量：6
《Chinese Medical Sciences Journal》2020年第1期31-42,共12页Qiufa Hao Baobao Wang Wei Zhang Wei Qiu Qianling Liu Xuemei Li 
the Natural Science Foundation of Beijing,China(Grant No.7122143).
Objective Injured tubular reabsorption is highlighted as one of the causes of increased albuminuria in the early stage of diabetic nephropathy;however,the underlying mechanism has not been fiilly elucidated.In this st...
关键词：inflammation insulin resistance ALBUMINURIA DIABETIC NEPHROPATHY PARTHENOLIDE 
Parthenolide inhibits the proliferation and induces the apoptosis of human uveal melanoma cells被引量：3
《International Journal of Ophthalmology(English edition)》2019年第10期1531-1538,共8页Song-Tian Che Li Bie Xu Li Hui Qi Peng Yu Ling Zuo 
Supported by the Health Special Project of Jilin Province Department of Finance (No.3D5177883429)
AIM: To explore the effect of parthenolide(PTL) on human uveal melanoma(UM) cells(C918 and SP6.5 cells) and its molecular mechanism. METHODS: Carboxyfluorescein succinimidyl amino ester(CFSE) assays and cell counting ...
关键词：PARTHENOLIDE UVEAL MELANOMA PROLIFERATION APOPTOSIS MITOCHONDRIAL pathway 
Hydrogen peroxide-induced apoptosis of human lens epithelial cells is inhibited by parthenolide被引量：2
《International Journal of Ophthalmology(English edition)》2018年第1期12-17,共6页Xing-Chao Shentu Xi-Yuan Ping Ya-Lan Cheng Xin Zhang Ye-Lei Tang Xia-Jing Tang 
Supported by the National Natural Science Foundation of China(No.81371000;No.81670834);the Natural Science Foundation of Zhejiang Province(No.LY17H090004);the Zhejiang Traditional Chinese Medicine Project(No.2013ZA080);the Fundamental Research Funds for the Central Universities(No.2017FZA7002)
AIM： To explore the effect of parthenolide on hydrogen peroxide（H_2O_2）-induced apoptosis in human lens epithelial（HLE） cells. METHODS： The morphology and number of apoptotic HLE cells were assessed using light ...
关键词：parthenolide apoptosis human lens epithelial cells hydrogen peroxide 
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