Parthenolide enhances the metronomic chemotherapy effect of cyclophosphamide in lung cancer by inhibiting the NF-kB signaling pathway  

作　　者：Zheng Cai Lang Gao Kai Hu Qi-Ming Wang 

机构地区：[1]Department of Internal Medicine,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Zhengzhou 450008,Henan Province,China [2]Department of Oncology,The No.1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine,Kunming 650021,Yunnan Province,China

出　　处：《World Journal of Clinical Oncology》2024年第7期895-907,共13页世界临床肿瘤学杂志（英文版）

基　　金：Supported by Joint Funding of Yunnan Ministry of Science and Technology,No.2019FF002-048;and Beijing Heathco Clinical Oncology Research Foundation,No.Y-Q201802-048.

摘　　要：BACKGROUND Parthenolide(PTL),a sesquiterpene lactone derived from the medicinal herb Chrysanthemum parthenium,exhibits various biological effects by targeting NF-kB,STAT3,and other pathways.It has emerged as a promising adjunct therapy for multiple malignancies.AIM To evaluate the in vitro and in vivo effect of PTL on cyclophosphamide(CTX)metronomic chemotherapy.METHODS The cytotoxicity of PTL and CTX on Lewis lung cancer cells(LLC cells)was assessed by measuring cell activity and apoptosis.The anti-tumor efficiency was evaluated using a tumor xenograft mice model,and the survival of mice and tumor volume were monitored.Additionally,the collected tumor tissues were analyzed for tumor microenvironment indicators and inflammatory factors.RESULTS In vitro,PTL demonstrated a synergistic effect with CTX in inhibiting the growth of LLC cells and promoting apoptosis.In vivo,metronomic chemotherapy com-bined with PTL and CTX improved the survival rate of tumor-bearing mice and reduced tumor growth rate.Furthermore,metronomic chemotherapy combined with PTL and CTX reduced NF-κB activation and improved the tumor immune microenvironment by decreasing tumor angiogenesis,reducing Transforming growth factorβ,andα-SMA positive cells.CONCLUSION PTL is an efficient compound that enhances the metronomic chemotherapy effects of CTX both in vitro and in vivo,suggesting its potential as a supplementary therapeutic strategy in metronomic chemotherapy to improve the chemotherapy effects.

关 键 词：Lung cancer PARTHENOLIDE CYCLOPHOSPHAMIDE Rhythmic chemotherapy NF-κB pathway 

分 类 号：R730.5[医药卫生—肿瘤]