抗震止痉胶囊Ⅱ号联合美多巴治疗帕金森病的临床研究  

Clinical Research on Kangzhenzhijing Capsule Ⅱ with Madopar for Parkinson’s Disease

作　　者：周义先 鲍远程[2] 

机构地区：[1]安徽省皖维医院 [2]安徽中医学院第一附院

出　　处：《中西医结合心脑血管病杂志》2007年第4期300-303,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的对帕金森病(PD)病人的发病形式、首发症状、体征、理化检验进行临床分析,观察抗震止痉胶囊Ⅱ号联合美多巴治疗效果,指导临床治疗。方法对30例住院的PD病人进行Webster症状评分,检测血常规、肝肾功能等检验指标。病人均接受抗震止痉胶囊Ⅱ号联合美多巴治疗1个疗程,然后在病人出院时进行再次Webster症状评分,总结治疗效果。结果在原有西药美多巴、金刚烷胺、安坦治疗基础上,加用抗震止痉胶囊Ⅱ号治疗后,Webster评分中度、重度病人治疗后积分较治疗前积分减少(P<0.05),轻度病人与治疗前比较无统计学意义(P>0.05),治疗有效率为90%。积分在动作减少、强直、姿势改变、行走时上肢摆动减少、步态、震颤、面容、言语、自我照顾等方面有统计学意义(P<0.05),在坐、起立运动方面无统计学意义(P>0.05)。治疗前后血常规、肝功能、肾功能指标无统计学意义(P>0.05)。结论抗震止痉胶囊Ⅱ号联合美多巴治疗能明显改善PD病人的运动功能,临床疗效明显,无明显副反应。Objective To observe the effect of Kangzhenzhijing capsule Ⅱ with madopar for Parkinson＇ s Disease （PD）. Methods Webster condition ratings, blood routine, liver and kidney function were test in 30 patients （pts） with PD preand post- therapy. All pts accepted Kangzhenzhijing capsule Ⅱ with madopar treatment. Results The first symptom was tremor, second one was rigidity and bradyki- nesia. The response rates was 90%. Webster condition ratings in bradykinesia, rigidity, postural change, upper arm swing slowing down, tremor, facial features, speech and care for oneself were significant difference pre - and post - therapy （ P 〈 0.05 ）. Conclusion Kangzhenzhijing capsule Ⅱ with madopar mould improve movement in pts with PD.

关 键 词：帕金森病 抗震止痉胶囊Ⅱ号 美多巴 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R256.46[医药卫生—临床医学]