血管内皮生长因子、微血管密度及Ki-67在宫颈鳞癌中的表达及意义  

Significance and expression of vascular endothelial growth factor,microvessel density and Ki-67 in human squamous-cell carcinoma of cervix

作　　者：叶琼[1] 胡宝春[1] 陈建熙[1] 

机构地区：[1]浙江省温州市第二人民医院病理科,温州325000

出　　处：《临床医学》2007年第3期89-90,共2页Clinical Medicine

摘　　要：目的探讨血管内皮生长因子(VEGF)、微血管密度(MVD)及Ki-67在宫颈鳞状细胞癌中的表达及意义。方法采用免疫组织化学S-P法测定45例宫颈鳞癌组织和10例正常宫颈组织中VEGF、Ki-67和F8的表达。结果宫颈鳞癌中VEGF的表达阳性率为77.78%,Ki-67标记指数(Ki-67LI)和MVD分别为12.7±4.1和37±10,VEGF表达水平与肿瘤恶性程度、Ki-67 LI和MVD计数呈正相关。结论VEGF有促进肿瘤细胞增殖及血管生成的作用,联合检测VEGF、Ki-67和F8可作为病理诊断的补充,对患者预后判断和治疗方案的选择有重要的参考价值。Objective To investigate the significance and expression of vascular endothelial growth factor（ VEGF）, microvessel density （MVD） and Ki - 67 in human squamous - cell carcinoma of cervix. Methods Expression of VEGF, Ki - 67 and F8 were detected by immunohistochemical S - P technique in cervical tissues of 45 cases of cervical squamous - cell carcinomas and 10 cases of normal cervical tissues. Results The positive rate of VEGF was 77.78%, Ki - 67 labeling index （ Ki - 67LI） and MVD were 12.7 ± 4. 1 and 37 ± 10 respectively . The expression of VEGF correlated positively with the grade of cervical squamous - cell carcinoma, Ki - 67LI and MVD. Conclusion VEGF plays a role in cancer cell proliferation and tumor anglogenesis. Evaluating of VEGF, Ki- 67 and F8 is the supplement of pathological diagnosis, which is important to evaluate the patient＇ s prognosis and select suitable therapy.

关 键 词：宫颈鳞癌 血管内皮生长因子 微血管密度计数 细胞增殖 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]