肝炎后肝硬化患者血小板参数变化的临床意义  

The clinical meaning of platelet's parameters change in cirrhosis of liver after hepatitis

作　　者：胡玫[1] 李莉[1] 安邦权[1] 金明[1] 费蓉[1] 张建[1] 

机构地区：[1]贵州省人民医院检验科,贵阳550002

出　　处：《微量元素与健康研究》2007年第2期14-15,共2页Studies of Trace Elements and Health

摘　　要：目的:探讨肝炎后肝硬化血小板计数(PLT)、平均血小板体积(MPV)、血小板宽度(PDW)和血小板压积(PCT)4项参数的改变,间接评估肝脏受损情况,判断有无出血倾向。方法:用Bayer ADVIA120全自动血细胞计数仪测定肝炎后肝硬化患者和正常健康体检者血小板各项参数,并对其中39例合并消化道出血者、89例未出血者和40例正常体检者血小板4项参数进行比较分析。结果:肝硬化组PLT、MPV、PCT值均小于正常对照组(P<0.05～0.005),PDW高于正常对照组(P<0.025)。其中消化道出血组血小板各项均低于未出血组。结论:随着肝炎后肝硬化患者病情加重,PLT、MPV、PCT明显减低,PDW明显增高,故血小板4项参数的测定对肝病患者出血倾向及功能判断有一定参考价值。Aim Studying four parameters＇ change in cirrhosis of liver after hepatitis： platelet count（PLT）, mean platelet volume（MPV）, platelet distribution width（PDW）, plateletocrit（PCT）, to evaluate the damage of liver, to judge whether having tendency of hemorrhage in liver or not. Methods To obtain all kinds parameters of platelet using Bayer Advia120 auto hematology analyzer in testing 40 healthy physical examinations and 128 patients with cirrhosis of liver after hepatitis. Meantime, the four parameters of 39 patients with gastrointestinal hemorrhage and 89 without among all patients and 40 healthy physical examinations were compared and analyzed. Results The value of PLT, MPV, PCT in cirrhosis group are lower than control group （P〈 0.05- 0. 005）, the value of PDW is higher than control group （P〈 0. 025）. In it, the four parameters of platelet in patients with gastrointestinal hemorrhage are all lower than patients without. Conclusion The more serious in patients with cirrhosis of liver after hepatitis, the less the value of PLT, MPV and PCT, the higher the value of PDW. So the test of four parameters has some reference value in judging of the tendency of hemorrhage and the function degree in patients with liver disease.

关 键 词：肝硬化 血小板 血小板压积 平均血小板体积 血小板分布宽度 

分 类 号：R575.2[医药卫生—消化系统]