海洛因依赖者记忆力与氧化应激的关系  

Relationship between memory and oxidative stress in patients with heroin dependence

作　　者：李武[1] 胡春凤[1] 郝伟[2] 成义仁[1] 李龙飞[1] 

机构地区：[1]山东济宁市精神病防治院,272051 [2]中南大学湘雅二医院精神卫生研究所

出　　处：《临床精神医学杂志》2007年第1期1-3,共3页Journal of Clinical Psychiatry

基　　金：国家重点基础研究专项经费973项目(003CB515400);2004年中南大学研究生教育创新工程项目(040143)

摘　　要：目的:探讨男性海洛因依赖者(MPHD)记忆力改变及其与氧化应激的关系。方法:对140例MPHD及75名健康者对照进行韦氏记忆量表(WMS)评估和氧化应激指标血清一氧化氮(NO)、丙二醛(MDA)、超氧化物歧化酶(SOD)、维生素C(VC)及总抗氧化能力(T-AOC)的检测。结果:MPHD组WMS的测验成绩显著差于对照组(P<0.05);MPHD组血清MDA水平高于对照组(P<0.05),T-AOC、VC、SOD水平低于对照组(P<0.05或P<0.01);随戒断时间延长,MPHD组的记忆商数(MQ)有升高的趋势(P>0.05),血清MDA含量有下降的趋势(P<0.01),T-AOC、SOD含量有升高的趋势(P<0.05)。MPHD组血清NO及MDA水平与WMS多个因子呈负相关(P<0.05或P<0.01),T-AOC、VC及SOD水平与WMS多个因子呈正相关(P<0.05或P<0.01)。结论:海洛因依赖者存在明显的记忆力损害与氧化抗氧化反应失衡;其记忆力损害可能与氧化应激有关,血清NO、MDA、SOD、VC、T-AOC可能是与记忆力密切相关的氧化应激指标。Objective： To explore the relationship between memory and oxidative stress in male patients with heroin dependence （MPHD）. Method： 140 MPHD and 75 healthy controls were evaluated the memory employing Weehsler memory scale （WMS）. The levels of serum nitric oxide （NO）, malondialdehyde （MDA）, superoxide dismutase （SOD）,vitamin C （VC） and total antioxidative capacity （T-AOC） were detected by eolorimetry. Results：The performances of WMS in MPHD group were signifieanfly lower than that in controls （ P 〈 0. 05）. Compared with healthy controls, MPHD had higher serum MDA level but lower T-AOC, VC, SOD levels （ P 〈 0. 05 or P 〈 0. 01 ）. With the lengthen of abstinent time, the memory quotient （MQ） showed a increasing trend（ P 〉 0. 05）, the levels of serum MDA showed a decreasing trend（ P 〈 0.01）, T-AOC and SOD both showed increasing trend （P 〈 0. 05）. The serum NO and MDA levels were negatively correlated to some factors of WMS, and the serum VC, SOD and T-AOC levels were positively correlated to some factors ofWMS （P 〈0.05 or P 〈0.01）. Conclusion： MPHD suffered from decreased memory and oxidative and anti-oxidative unbalance. Oxidative stress is involved in impaired memory, and serum NO, MDA, SOD, T-AOC and VC may be responsible for impaired memory of MPHD.

关 键 词：物质依赖 海洛因 记忆力 氧化应激 

分 类 号：R749.6[医药卫生—神经病学与精神病学]