小鼠肺腺癌高、低转移潜能亚系（C_6／C_7）生物学特性的比较  

Comparative Studies of the Biological Properties of Low and High Metastatic Potential Sublines(C_6/C_7)

作　　者：张海伟[1] 王惠华[1] 司徒锐[1] 廖剑辉[1] 

机构地区：[1]暨南大学医学院病理解剖学教研室

出　　处：《暨南大学学报（自然科学与医学版）》1996年第2期6-10,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：利用小鼠肺腺癌高、低转移潜能亚系（Ｃ６／Ｃ７）细胞，在体外对其细胞移动性、粘连性、细胞骨架以及内源性非特异性酯酶的表达进行比较。结果小鼠肺腺癌高、低转移潜能亚系（Ｃ６／Ｃ７）细胞体内转移能力与其体外移动性、粘连性呈负相关；与其细胞胞浆骨架网络分布不均、紊乱，常纠集于胞核一侧以及细胞内非特异性酯酶的高表达里正相关。提示：癌细胞体内转移能力与其体外移动性、粘连性不一定相互平行：癌细胞浆骨架分布不均、紊乱，尤其常纠集于胞核一侧的现象，以及内源性非特异性酯酶的高表达，很可能是高转移性癌细胞的重要生物学表型。Abstract The low and high metastatic potential sublines (C6/C7), isolated from mouse lung adenocarcinooma cell line(LA795) by single cell culture technique, had been demonstrated the differat ability of lung metastasis in nude mice by transplanting into the webbed toes of nude micce for 30 days andshowed the different morphology significantly . In this paper, the variationsof the motility, adhesion, proliferation , cytoskeleton and the expression of endogenous non-specificesterase in these variants were compared in vitro. The results demonstrated that the metastatic potential in vivo was correlated with the degree of the cellular prolifelation, irregular and uneven distribution of cytoskeleton , and the expression of endogenous non--specific esterase. but it might be not parallel to motility or adhesion in vitro.Keywoads: mouse lung adenocarcinoma, motility, adhesion, prolifelation, non-specific esterase,heterogenicity

关 键 词：肺腺癌 癌细胞 高转移亚系 生物学 低转移亚系 

分 类 号：R734.2[医药卫生—肿瘤]