喉黏膜白斑和喉鳞状细胞癌中survivin表达的意义  

Role of survivin expression in laryngeal leukoplakia and laryngeal squamous cell carcinoma

作　　者：谢洪[1] 张宝泉[2] 尹金淑[1] 周晓红[1] 

机构地区：[1]北京世纪坛医院耳鼻喉科,北京100038 [2]中国医学科学院北京协和医科大学北京协和医院耳鼻喉-头颈外科

出　　处：《山西医科大学学报》2007年第4期313-317,共5页Journal of Shanxi Medical University

摘　　要：目的探讨survivin蛋白在喉黏膜白斑和喉鳞状细胞癌中的表达情况及其意义。方法通过免疫组化法对28例喉黏膜白斑、46例喉鳞状细胞癌、24例癌旁组织和16例正常喉黏膜中survivin的表达情况进行检测。结果发现survivin蛋白在喉黏膜白斑、喉癌组织和癌旁组织中的阳性表达率分别为46.43%(13/28)、71.74%(33/46)、33.33%(8/24);在正常黏膜组织中没有表达,喉癌组中的阳性表达率分别显著高于正常组织、癌旁组织、喉黏膜白斑中的表达率。中重度不典型增生喉黏膜白斑组的阳性表达率(66.67%)显著高于轻度不典型增生的阳性表达率(23.08%),发生了恶变的5例喉黏膜白斑组织中survivin蛋白均为阳性表达,但与喉癌的发生部位、分级、分期、淋巴结转移以及病理分级没有关联。结论survivin在中重度不典型增生喉黏膜白斑组织和喉癌组织中过度表达,参与了喉癌的形成,是喉癌形成的一个早期事件,可望成为预测喉癌癌前病变发展成恶性肿瘤的一个诊断工具。Objective To study the expression of survivin and its role in laryngeal leukoplakia and laryngeal squamous cell carcinoma. Methods The expression of survivin protein was detected by immunohistochemistry in 28 cases of laryngeal leukoplakia, 46 cases of laryngeal squamous cell carcinoma, 24 cases of adjacent nontumorous laryngeal epithelium and 16 cases of normal laryngeal epithelium. Results The positive rates of survivin protein expression in laryngeal leukoplakia, laryngeal carcinoma, adjacent nontu- morous laryngeal epithelium and normal laryngeal epithelium were 46.43 % （ 13/28）, 71.74 % （33/46）, 33.33 % （8/24）, respectively. The positive rate of survivin protein expression in laryngeal carcinoma was significantly higher than that in normal laryngeal epithelium, the adjacent nontumorous laryngeal epithelium and laryngeal leukoplakia, The positive rate of survivin protein expression in moderate/severe atypical hyperplasia laryngeal leukoplakia（66.67% ）was significantly higher than that in mild atypical hyperplasia laryngeal leukoplalda（23.08% ）. But there were no statistically significant correlations between survivin protein expression and the clinicopathological characteristics of tumor site, T-stage, pathological grading, UICC-stage and lymph node metastasis（ P 〉 0. 05 ）. The expression of survivin protein were all positive in 5 cases of the laryngeal leukoplakia group which turned into laryngeal carcinoma later. Conclusion There is overexpression of survivin in the laryngeal carcinoma. The expression of survivin might play an important role in the carcinogenisis of laryngeal squamous cell carcinoma, and might be an early event during laryngeal carcinogenesis. It could be a diagnostic marker for evaluating the malignant potential of laryngeal precancerosis lesion.

关 键 词：肿瘤 鳞状细胞 喉黏膜 白斑 存活素 

分 类 号：R730.261[医药卫生—肿瘤]