正交设计法优化硝酸益康唑的合成工艺  

Optimization of the synthesis of econazole nitrate by orthogonal experimental design

作　　者：邵律成[1] 陈红[1] 王小燕[2] 何邦平[2] 吕加国[2] 盛春泉[2] 

机构地区：[1]第二军医大学研究生管理大队,上海200433 [2]第二军医大学药学院,上海200433

出　　处：《药学实践杂志》2007年第2期102-103,共2页Journal of Pharmaceutical Practice

摘　　要：目的:优化抗真菌药物硝酸益康唑的合成工艺。方法:采用正交设计法,重点考察反应温度、催化剂、反应时间及溶剂四个因素对收率的影响。结果:溶剂对反应收率的影响最为显著,其次是反应时间和催化剂。结论:新工艺原料价廉易得,反应条件温和,后处理简便,收率高。Objective ： To optimize the synthesis of econazole nitrate, a useful antifungal agent. Methods ： Orthogonal experimental design is used and the influence of temperature, catalyst, reaction time and solvent on the yield is investigated. Results： Solvent is more important than reaction time and catalyst. Conclusion： The new method has several advantages such as cheap reactants, facile reaction condition, convenient operation and high yield.

关 键 词：正交设计 益康唑 合成 

分 类 号：R914[医药卫生—药物化学]