盐酸利莫那班的合成  

Synthesis of Rimonabant Hydrochloride

作　　者：汤立合[1] 陶林[1] 陈合兵[2] 仲伯华[1] 

机构地区：[1]军事医学科学院毒物药物研究所 [2]军事医学科学院仪器分析测试中心,北京100850

出　　处：《中国医药工业杂志》2007年第4期252-254,共3页Chinese Journal of Pharmaceuticals

摘　　要：对氯苯丙酮经硅烷化制得烯醇硅醚,与草酰氯单乙酯缩合得到α,γ-二酮酸酯,再经成腙、环合、水解、酰胺化和成盐等反应制得盐酸利莫那班,总收率约46%。Rimonabant hydrochloride was synthesized from 4-chloropropiophenone by silylation, acylation with ethyl oxalyl chloride to give α,γ-diketo ester, which was subjected to hydrazone reaction, cyclization, hydrolysis, amidation and salt formation with an overall yield of about 46 %.

关 键 词：利莫那班 大麻素受体-1选择性阻断剂 减肥药 合成 

分 类 号：R979.9[医药卫生—药品]