卡莫司汀缓释植入剂对S180肉瘤的抑制作用  

Inhibition in Slow-release Implants of Carmustine for S180 Sarcoma

作　　者：张婕[1] 宋加金[2] 张红军 俞建江 苏红清 刘恩祥 赵云峰[4] 孔庆忠[1] 

机构地区：[1]山东大学生命科学学院 [2]曲阜师范大学科研处 [3]山东蓝金生物工程有限公司,山东省济南市250100 [4]曲阜师范大学生命科学学院,山东省曲阜市273165

出　　处：《曲阜师范大学学报（自然科学版）》2007年第2期106-109,共4页Journal of Qufu Normal University(Natural Science)

摘　　要：以PLGA为载体的卡莫司汀缓释植入剂能有效抑制小鼠S180肿瘤的生长.含15%和25%卡莫司汀的缓释植入剂对肿瘤的抑制率分别为99%和98%(P<0.05).观察2个月发现,对照组小鼠平均存活时间为30.4天,15%卡莫司汀组小鼠平均存活52.7天(P<0.05),25%卡莫司汀组小鼠平均存活20天,瘤内注射组小鼠平均存活10天.The growth of S180 sarcoma in mouse is significant inhibited by BCNU-PLGA implants. Intralesional implantation of BCNU at 15% and 25% by weight in polymer result in a tumor growth inhibition of 99% and 98% （p〈0.05）, respectively. Compared to control group （30. 4 days）, BCNU at 15% significantly extend the mean survival time to 52.7 days, observe in two months. BCNU at 25% administere intralesionally in polymer or in injection significantly inhibited tumor growth, which is debilitated by systemic toxicities and seen with BCNU in either formulations.

关 键 词：卡莫司汀 缓释植入剂 S180 肿瘤抑制 载体 聚乳酸 

分 类 号：R730.54[医药卫生—肿瘤]