5-羟色胺转运体启动子区基因多态性与强迫症的关联分析  

The association of serotonin transporter promoter region polymorphism with obsessive compulsive disorder

作　　者：周云飞[1] 张亚林[2] 胡纪泽[1] 刘铁榜[1] 刘妹 闫小华[1] 余常红[1] 赵幸福[2] 

机构地区：[1]广东深圳市康宁医院,518003 [2]中南大学湘雅二院精神卫生研究所 [3]深圳市人民医院

出　　处：《临床精神医学杂志》2007年第2期76-78,共3页Journal of Clinical Psychiatry

基　　金：深圳市科技计划资助项目(JH200505180193A)

摘　　要：目的:探索汉族人群中的5-羟色胺转运体启动子区(5-HTTLPR)基因多态性与强迫症的发病关系。方法:对强迫症患者(强迫症组)和正常对照者(对照组)分别采用聚合酶链反应扩增片断长度多态技术测定基因型。结果:强迫症组与对照组5-HTTLPR的基因型频率无显著性差异;两组的等位基因频率有显著性差异。L等位基因与强迫症呈正关联(OR=1.929,P<0.05)。结论:5-HTTLPR基因多态性的L等位基因与强迫症相关联,是强迫症的危险因子。Objective：To explore the association between polymorphism of serotonin transporter promoter region （5-HTTLPR） and the pathogenesis of obsessive compulsive disorder in the Han nationality. Method： Patients with obeessive-compulsive disorder and normal controls were genotyped for the 5-HTTLPR with polymerase chain reaction amplification fragment length polymorphism techniques. Results：There was no significant difference between patients with obsessive compulsive disorder and normal controls in the frequencies of genotype for 5-HTrLPR.There was a significant difference on allele frequency of 5-HTrLPR, Allele L of 5-HTrLPR positively associated with obsessive com- pulsive disorder（ OR = 1. 929, P 〈 0.05）. Conclusion： There was a relationship between Allele L of 5-HTTLPR gene polymorphism and obsessive compulsive disorder in the Han nationality. Allele L may be a risk factor to the pathogenesis of obsessive-compulsive disorder.

关 键 词：强迫症 5-羟色胺转运体 启动子区 基因多态性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]