晚发性和早发性精神分裂症临床特征比较  

Comparison of clinical characteristics between the early onset and late onset schizophrenia

作　　者：纪家武[1] 翁塞铮[1] 黄少雅[1] 

机构地区：[1]福建医科大学教学福州第四医院,350007

出　　处：《临床精神医学杂志》2007年第2期104-105,共2页Journal of Clinical Psychiatry

摘　　要：目的:了解早发性和晚发性精神分裂症的临床特征。方法:用阳性症状量表(SAPS)、阴性症状量表(SANS)评定临床症状;临床疗效总评量表(CGI)、治疗中出现的症状量表(TESS)评定临床疗效及不良反应;用躯体异常量表(Waldrop scale)测量软体征。对早发性精神分裂症和晚发性精神分裂症患者各50例进行对照研究。结果:早发性精神分裂症遗传倾向明显,软体征异常率高,有更明显的阴性症状,治疗效果较差,不良反应更明显。晚发性精神分裂症女性明显多于男性,以幻觉、妄想、偏执观念为主要临床特征。结论:早发性和晚发性精神分裂症各有其临床特征。早发性比晚发性精神分裂症的遗传负荷和胚胎发育异常程度高,治疗效果和预后较差。Objective： To compare the clinical characteristics between early onset and late onset schizophrenia. Method：50 early onset and 50 late onset schizophrenic patients were investigated. The score for the assessment of positive symptoms （SAPS） and the score for the assessment of negative symptoms （SANS） were used to assess the clinical symptoms. The elinical global impression scale （CGI） and the treatment emergent symptom scale （TESS） were used to evaluate the clinical efficacy and adverse effect. The Waldrop scale was used to measure the soft neurological signs. Results：The patients in early onset group had more hereditable feature,more soft neurological signs, more negative symptoms, worse clinical efficacy and more side effects. The clinical characteristics of the patients in late onset group were more females, more hallucinations, more delusions and more paranoid ideas. Conclusion： There is a different clinical characteristics between the patients with early onset and the patients with late onset schizophrenia. The patients with early onset schizophrenia trend to have high heredity and more heteroplasia in embryo, which result in poor treatment efficacy and poor prognosis.

关 键 词：早发性精神分裂症 晚发性精神分裂症 软体征 

分 类 号：R749.3[医药卫生—神经病学与精神病学]