乳腺癌组织中Ang-2和受体Tie2的表达及与血管生成的关系  

Expression of Ang-2/Tie2 and its relation with angiogenesis in breast carcinoma

作　　者：户庄[1] 谷元廷[1] 僧靖静[1] 

机构地区：[1]郑州大学第一附属医院普外科,河南郑州450052

出　　处：《中华肿瘤防治杂志》2007年第3期196-198,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨Ang-2和Tie2的表达与乳腺癌浸润和转移的关系。方法:选用42例乳腺癌标本、16例乳腺纤维腺瘤及13例正常乳腺组织,以SP法进行Ang-2、Tie2及CD34标记的微血管密度(MVD)的检测,并分析其与临床病理特征的关系。结果:在乳腺癌组织中,Ang-2、Tie2阳性表达率分别为95.2%和92.9%;明显高于正常乳腺组织(15.4%、12.5%)和乳腺纤维腺瘤组织(15.4%,15.4%),P=0.001。CD34标记的MVD与Ang-2、Tie2密切相关。结论:人乳腺癌中血管生成增加,Ang-2和Tie2在乳腺癌血管生成和进展中可能起重要作用。OBJECTIVE：To study the expressions of Ang-2 and Tie2 in breast cancer and the relation with invasion and metastasis. MEHTODS： The immunohistochemical technique SP was used to detect the Ang-2,Tie2 and MVD which was marked by CD34 in 42 cases of breast cancer , 16 cases of breast fibroadenoma and 13 cases of normal breast, the associations between their expressions and the features of clinical pathology of invasive ductal breast carcinoma were al- so analyzed. RESULTS： The positive rates of Ang-2 and Tie2 in malignant breast tumor were 95.2% and 92.9%, much higher than those in normal breast and breast fibroadenoma which were 15.4%0, 15.4 % and 12.5 %, 12.5 %, P= 0. 001. There were close correlations between Ang-2 and CD34, Tie2 and CD34. CONCLUSIONS： Angiogenesis is enhanced in breast carcinoma. Ang-2/Tie2 may play a critical role in promoting tumor angiogenesis and progression in human breast carcinoma.

关 键 词：乳腺肿瘤 ANG-2 受体 TIE-2 新生血管化 病理性 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]