淋巴结转移10枚及以上的原发乳腺癌回顾性研究  

Retrospective study on primary breast cancer with 10 and more axillary lymph nodes

作　　者：冯玉钰[1] 宁连胜[2] 

机构地区：[1]天津医科大学,天津300070 [2]天津市肿瘤医院乳腺一科,天津300060

出　　处：《中华肿瘤防治杂志》2007年第3期209-212,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:回顾性分析10枚及以上腋窝淋巴结转移原发乳腺癌各临床病理因素、辅助治疗方法与预后的关系。方法:对病理确诊且腋窝淋巴结转移10枚及以上原发乳腺癌患者186例,采用χ2检验和COX模型,分析诊断年龄、肿物大小、临床分期、术式、术前化疗状态、术后化疗状态、术后放疗状态、术后内分泌治疗状态、受体状态与预后的关系。结果:临床病理因素和辅助治疗方法与3、5年复发率和3、5年转移率差异均无统计学意义,P>0.05。肿物大小与10年生存率、5年和10年无瘤生存率差异均有统计学意义,P<0.05。临床分期10年无瘤生存率差异有统计学意义(P=0.030),而与5、10年生存率和5年无瘤生存率差异均无统计学意义,P>0.05。术后辅助化疗、术后辅助放疗和术后辅助内分泌治疗5、10年无瘤生存率及5、10年生存率差异均有统计学意义,P<0.05。诊断年龄、术式、激素受体状态和术前化疗状态与5年无瘤生存率、10年无瘤生存率及5、10年生存率差异均无统计学意义,P>0.05。COX模型分析结果仅术后化疗状态是与预后相关的辅助治疗方法。结论:对于10枚及以上淋巴结转移原发乳腺癌其预后与临床病理因素和辅助治疗的选择相关。OBJECTIVE：To assess the correlations between prognosis and clinicopathological features, adjuvant therapy in breast cancer patients with 10 and more lymph nodes metastasis. METHODS： A total of 186 breast cancer patients histologically with 10 and more lymph nodes metastasis treated in Tianjin Cancer Hospital were studied between January, 1989 and December, 1994. Chi square test was used to analyze the correlations between prognosis and diagnosed age, tumor size, clinical stage, operation method, preoperative chemotherapy status, postoperative chemotherapy status, postoperative radiotherapy status, postoperative endocrine therapy status, hormone receptors status. RESULTS： There were no significant difference between clinicopathological features, adjuvant therapy and 3-year recurrence rate, 5-year recurrence rate, 3-year metastasis rate, 5-year metastasis rate, P〈0.05. There were significant differences between tumor size and 10-year overall survival, 5-year disease free survival, 10-year disease free survival, P〈0.05. There were significant differences between clinical stage and 10-year disease free survival, P=0. 030. There were significant differences between postoperative chemotherapy status, postoperative radiotherapy status, postoperative endocrine therapy status and 5-year disease free survival, 10-year disease free survival, 5-year overall survival, 10-year overall survival, P〈0.05. There were no significant differences between diagnosed age, operation method, hormone receptors status, preoperative chemotherapy status and 5-year disease free survival, 10-year disease free survival, 5-year overall survival, 10-year overall survival, P〉0.05. Cox model showed that only postoperative chemotherapy was correlated with prognosis. CONCLUSION： There were correlations between prognosis and clinicopathological features, adjuvant therapy choices in patients with 10 more positive lymph nodes.

关 键 词：乳腺肿瘤/病理学 淋巴转移 预后 回顾性研究 

分 类 号：R737.9[医药卫生—肿瘤]