原发性肝癌三维适形放疗114例疗效评价  

Evaluation of three-dimensional conformal radiotherapy on 114 patients with primary hepatocellular carcinoma

作　　者：郭守芳[1] 李万湖[1] 马建[1] 袁双虎[1] 侯栋梁[1] 于甬华[1] 范廷勇[1] 

机构地区：[1]山东省肿瘤医院CT室,山东济南250117

出　　处：《中华肿瘤防治杂志》2007年第4期302-303,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：观察三维适形放射治疗（three-dimensional conformal radiotherapy,3DCRT）原发性肝癌的临床疗效.对114 例原发性肝癌患者在CT 定位下以3～5 mm层厚连续扫描,静脉双期碘造影剂增强扫描,精确定位治疗靶区并制定3DCRT计划,使90%等剂量曲线包绕计划靶体积（planning target volume,PTV）.以Varian 2100C 直线加速器实施放疗计划照射剂量1.8～2 Gy/次,5次/周,总剂量50～66 Gy,总疗程5～7周.治疗后1个月33例部分缓解,3个月42例部分缓解,6个月53例部分缓解.1、2和3年生存率分别为52.6%、35.1%和 28.9%.初步研究结果提示,3DCRT是原发性肝癌的有效无创治疗手段.The objective of this study was to analyze the therapeutic value of conventional fractionation conforreal radiotherapy in the treatment of primary hepatocellular carcinoma （HCC）. Altogether 114 patients with HCC underwent three-dimensional conformal radiotherapy （3D CRT） in conventional fractionation radiotherapy received 1.8- 2.0 Gy per fraction, 5 fractions per week with the total dose of 50-66 Gy/5-7 w. The planning target volume were covered with 90% isodose curve, using 6 MV or 15 MV X-ray. All patients were followed-up by CT, blood, hepatic function and alpha-fetoprotein. One month after 3D CRT,33 patients achieved partial response（PR）; 42 patients achieved PR in 3 months after 3D CRT, as well as 53 patients in 6 months. The survival rates in 1, 2 and 3 years were 52.6%, 35.1% and 28.9%, respectively. In conclusion, 3D-CRT with conventional fractionation radiotherapy is a non-invasive technique highly suitable for HCC and it has a sure short-term efficacy and less side-effect.

关 键 词：肝肿瘤/放射疗法 放射疗法 适形 放射治疗剂量 

分 类 号：R735.7[医药卫生—肿瘤]