硫醇转移酶和硫氧还蛋白系统在白内障中的研究  

Thioltransferase and Thioredoxin System in Cataract

作　　者：柴飞燕[1] 严宏[1] 

机构地区：[1]第四军医大学唐都医院眼科,西安710038

出　　处：《眼科学报》2007年第1期15-19,共5页Eye Science

摘　　要：晶状体透明性的维持需要平衡的氧化还原状态和恰当的巯基/二硫化物比例,其丰富的谷胱甘肽和内在修复酶系统作为重要的防御屏障对于维持晶状体功能非常重要,然而,在老化白内障晶状体中,谷胱甘肽含量显著下降。近年对硫醇转移酶和硫氧还蛋白系统的研究发现:硫醇转移酶特异地使蛋白质与谷胱甘肽形成的二硫化物脱硫醇,恢复蛋白质的自由巯基,维持蛋白质或酶的功能;硫氧还蛋白系统能使蛋白质二硫化物脱硫醇,是细胞内氧化还原稳态的重要调节子。两者协同作用能有效地修复晶状体蛋白质和酶的巯基,维持晶状体的功能。The lens depends on a balanced redox state and SH/-S-S- ratio for maintaining its transparency. The endogenous high level of glutathione （GSH） and its intrinsic repair enzymes are very important lines of defense for the health of the lens. However, ageing lenses or cataract lenses show an extensively diminished size of GSH pool. The research in thioltransferase （3Tase） and thioredoxin （Trx） system show TTase can specifically dethiolate protein-S-S-glutathione and restore protein free SH groups for proper enzymatic or protein functions; Trx system can dethiolate protein disulfides and thus is an extremely important regulator for redox homeostasis in the cells. The two enzymes may work synergistically to repair thiols in lens proteins and enzymes and maintain the function of the lens effectively. Eye Science 2007;23：15-19.

关 键 词：硫醇转移酶 硫氧还蛋白系统 白内障 晶状体透明性 

分 类 号：R776.1[医药卫生—眼科]