“益气解毒”法对力竭性游泳所致气虚体质状态小鼠运动能力及免疫功能的影响  

Effect of Qi-Boosting and Toxin Resolving Method on Swimming Ability and Immune Function Among the Mice with a Constitutional Status of Qi Deficiency Induced by Exhaustive Swimming Exercising

作　　者：成细华[1] 杨美辉 田道法[1] 喻嵘[1] 胡伟[1] 魏开春[1] 

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]湖南省地震局卫生所,湖南长沙410003

出　　处：《中华中医药学刊》2007年第4期712-714,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(30271678;30572408);国家中医药管理局基金项目(02-03JP29)

摘　　要：目的:观察中药“益气解毒”法对力竭性游泳所致气虚体质状态小鼠运动能力及免疫功能的影响。方法:实验动物随机分为4组,正常对照组常规饲养,其余3组动物采用控制进食量,150g/(kg.d)加力竭游泳造成气虚体质状态,并分别灌服生理盐水、“益气解毒”颗粒或贞芪颗粒,连续16天。在实验开始后第4、8、12、15天记录力竭游泳时间,实验第16天处死动物,观察免疫机能指标的变化。结果:与模型组动物相比较,“益气解毒”法能明显延长小鼠负重游泳时间(P<0.01);激活网状内皮系统的吞噬功能(P<0.01),提高外周血中T淋巴细胞比率(P<0.01)。结论:“益气解毒”法有增强气虚体质状态小鼠机体免疫功能和抗疲劳作用。Objective： To investigate the effect of Qi-Boosting Toxin-Resolving Granule （QBTRG） on swimming ability and immune function among the mice with a status of Qi deficiency induced by exhaustive swimming exercising. Methods： Forty-eight mice were randomly divided into 4- groups, i.e. treating group （TG）, positive controlling group （ PCG）, modeling group （MG） and healthy controlling group （ HCG）, with 12 animals in each group. The mice in TG, PCG and HCG were all given a controlled amount of food intake at 150g/（ kg · d） plus exhaustive swimming exercising to make their them in a status of Qi deficiency, and those in HCG were kept in a normal feeding situation. Meanwhile, the animals in the former groups were given QBTRG, Zhenqi Right-Supporting Granule （ZQRSG） and normal saline respectively, in a concecutive way lasted for 16 days. Then,the animals in all the four groups were measured the exhaustive swimming time to evaluate their exercising ability at the 4^th , 8^th, 12^th and 15^th day from the beginning of experiment respectively and all the mice were killed at the 16^th day to collect blood samples for immune function determinatiouamong them. Results： The exhaustive swimming time in TG was significantly prolonged than those in MG （ P 〈0.01 ） , with obviously improved values of phagocytic function of the reticuloendothelial system （ P 〈 0.01 ） and rate of T-lymphocyt （ P 〈 0.01 ） in the mice of TG. Conclusion： QBTRG holds the effects on the animals with a constitutional status of Qi deficiency to improve their immune function and to make the fatigue mice in a excitating status.

关 键 词：益气解毒 气虚 体质状态 免疫机能 

分 类 号：R-33[医药卫生]