聚乙二醇干扰素α-2a致多发性肌炎合并间质性肺炎  

Polymyositis complicated by interstitial pneumonia after peginterferon α-2a use

作　　者：何书华[1] 李丽[1] 刘日升[1] 

机构地区：[1]海南医学院附属医院,海南海口570102

出　　处：《药物不良反应杂志》2007年第2期131-132,共2页Adverse Drug Reactions Journal

摘　　要：1例53岁慢性乙型病毒性肝炎女性患者皮下注射聚乙二醇干扰素α-2a 135μg/周,共18次。停药18d后出现咳嗽、呼吸困难、双上肢肌力Ⅳ级,双下肢肌为Ⅲ级。胸片显示双肺间质性炎症。实验检查:CK-MB 329U/L,CK 4099U/L。患者经抗病毒和对症治疗以及甲泼尼龙冲击治疗后,CK-MB及CK分别降至13U/L及40U/L。Summary： A 53-year-old woman with chronic viral hepatitis B was administered with peginterferon α -2a 135 ixg/week subcutaneously for 18 doses. After a 18 d discontinuation of the drug, she occurred cough and dyspnea. Myodynamia of both upper limbs was grade Ⅳ and both lower limbs was grade Ⅲ, A chest x-ray showed interstitial inflammation in the lungs. Laboratory tests revealed CK-MB 329 U/L and CK 4 099 U/L. The levels of CK-MB and CK in the patient were decreased to 13 U/L and 40 U/L respectively, after antiviral therapy, symptomatic therapy and pulse methylprednisolon therapy.

关 键 词：聚乙二醇干扰素Α-2A 多发性肌炎 间质性肺炎 不良反应 

分 类 号：R746[医药卫生—神经病学与精神病学] R595.3[医药卫生—临床医学]