癌症患者生命质量测定量表体系共性模块的研制(三):反应度分析  

Development of the General Module of the System of Quality of Life Instruments for Cancer Patients: Responsiveness Analysis

作　　者：万崇华[1] 罗家洪[1] 杨铮[1] 孟琼[1] 张晓磬[1] 卢玉波[2] 汤学良[2] 张灿珍[2] 

机构地区：[1]昆明医学院公共卫生学院,云南昆明650031 [2]云南省肿瘤医院,云南昆明650031

出　　处：《癌症》2007年第4期337-340,共4页Chinese Journal of Cancer

基　　金：云南省自然科学基金(No.99C0016G)~~

摘　　要：背景与目的:我们已经开发了癌症患者生命质量测定量表体系共性模块(quality of life instruments for cancer patients-general module,QLICP-GM),并对其信度、效度进行了评价。本文拟对其反应度进行分析。方法:用QLICP-GM量表测定5种癌症600例患者治疗前后的生命质量,采用传统假设检验并结合效应大小、标准化反应均数等指标以及等效检验方法进行分析。结果:躯体功能、心理功能、共性症状及副作用3个领域和总量表均发现统计学意义的变化,其标准化反应均数在0.16～0.67之间;等效检验也发现这些领域和总量表治疗前后不具等效性。结论:QLICP-GM具有一定的反应度,可用于临床生命质量测评。BACKGROUND ＆ OBJECTIVE： The general module of the system of quality of life instruments for cancer patients, QLICP-GM, has been developed and its reliability and validity has been evaluated by us. This study was to analyze its responsiveness. METHODS： The quality of life of 600 patients with 5 kinds of cancer was measured using QLICP-GM before and after treatment. Traditional significance tests with some indices, such as effect size, standardized response mean and equivalence, were applied to evaluate responsiveness. RESULTS： The quality of life score changed significantly after treatment on 3 domains：physical function, psychologic function, and general symptoms and side effects. The standardized response mean of the overall instrument ranged from 0.16 to 0.67. Equivalence test showed no equivalence on quality of life score changes of these domains and the overall instrument. CONCLUSION： QLICP-GM possesses reasonable responsiveness and can be used in clinical measurement of quality of life for cancer patients.

关 键 词：肿瘤 生命质量 反应度 效应大小 标准化反应均数 等效检验 

分 类 号：R73-31[医药卫生—肿瘤]