脑梗死患者血清胆红素及血脂变化的临床意义探讨  

Clinical Significance of Serum Bilirubin and Blood-Lipid Level in Patients with Cerebral Infarction

作　　者：王钟秀[1] 杨林花[1] 刘秀娥[1] 薛村水[2] 李光来[2] 张媛[3] 闫文林[3] 

机构地区：[1]山西医科大学第二医院 血液科,太原030001 [2]山西医科大学第二医院 神经内科,太原030001 [3]山西医科大学第二医院血液科,太原030001

出　　处：《血栓与止血学》2007年第2期73-75,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的观察脑梗死患者血清胆红素水平的变化,探讨其与血脂浓度变化的关系及临床意义。方法选择脑梗死患者组64例和对照组32例,应用生化方法(全自动生化分析仪)测定血清总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)及血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、脂蛋白- a(Lp-a)、载脂蛋白A1(ApoA)、载脂蛋白B(ApoB)浓度,并进行统计学分析。结果脑梗死患者血清TBIL、IBIL浓度显著高于对照组,有显著性差异(p<0．01),DBIL浓度也明显高于对照组,有显著性差异(P<0．05);血清TC、TG、LDL及ApoA浓度较对照组增高,有显著性差异(P<0．01),HDL、ApoB浓度较对照组低,有显著性差异(P<0．05);Lpia浓度也较对照组升高,但无统计学意义(P>0．05);且血清IBIL浓度与LDL浓度呈正相关(r=0．213,P<0．05)。结论胆红素、血脂的异常变化与脑梗死的发生、发展有一定关系。Objective To explore the change of serum bilirubin and blood-lipid level in patients with cerebral infarction. Methods Serum total bilirubin, direct bilirubin, indirect bilirubin, total cholesterol, triglycerides, serum high-density lipoprotein cholesterol, serum low-density lipoprotein cholesterol, lipoproteina,apolipoprotein A1, apolipoprotein B was measured in 64 patients with cerebral infarction （the observed group） and 32 healthy controls. Apply SPSS 10.0 for windows to deal with all data, T test was used to compare between the groups. Results Serum bilirubin in patients in the observed group total bilirubin 16. 464± 7. 442μmol/L,direct bilirubin 3. 264± 1. 719 μmol/L,indirect bilirubin 13. 201± 6. 130 μmol/L was higher than＇the patients in the control group. P 〈0.01 （TBIL）, P 〈0.05 （IBIL） ;the level of indirect bilirubin was in positive correlation with the concentration of lowdensity lipoprotein cholesterol （ r = 0.213, P 〈 0.05 ）. Serum total cholesterol, triglycerides, serum high-density lipoprotein cholesterol, apolipoprotein B was significantly increased in patients in the observed group （P 〈0.01 ） ,serum low-density lipoprotein cholesterol, apolipoprotein A1 in patients in the observed group was significantly decreased in the patients in the observed group（ P 〈 0.01 ）. Conclusion It suggested that there were pathophysiological relationships between cerebral infarction and serum levels of bilirubin and blood-lipid.

关 键 词：脑梗死 胆红素 血脂 

分 类 号：R743.3[医药卫生—神经病学与精神病学]