细胞因子信号传导抑制蛋白-1(SOCS-1)研究进展  

Progress of Study on Suppressor of Cytokine Signaling-1——Review

作　　者：杨海平[1] 戴敏[1] 张东华[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院血液科

出　　处：《中国实验血液学杂志》2007年第2期437-440,共4页Journal of Experimental Hematology

摘　　要：细胞因子信号传导抑制蛋白(suppressor of cytokine signaling,SOCS)家族是一类由细胞产生并反馈性阻断细胞因子信号转导过程的负性调节因子,最先发现的是SOCS-1。SOCS-1可抑制IL-6、LIF、OSM、INF-γ以及GH等多种细胞因子的信号转导,对体内多种免疫反应的激活起调控作用。SOCS-1异常表达与多种疾病的发病相关,在急慢性白血病、类风湿性关节炎、肝硬化和肝癌的发病中起重要作用。本文就SOCS-1与细胞因子的关系及其临床研究进展进行综述。Suppressor of cytokine signaling （SOCS） is a new family of proteins produced in cells. It may play an important role in classic negative feedback loop to regulate cytokine signal transduction. SOCS-1 was observed and confumed firstly. Expression of SOCS-1 can inhibit cytokine signal transduction of some cytokines, such as IL-6, LIF, OSM,INF-γ, GH, and so on, many immune responses are regulated by them in vivo. Abnormal expression of SOCS-1 is closely related to some human diseases. It plays an important role in the development of leukemia, rheumatoid arthritis, liver cirrhosis and liver cancer. In this review, the advances of research on the relationship between SOCS-1 and cytokine, and its correlation with some diseases were summarized.

关 键 词：细胞因子信号传导抑制蛋白-1 细胞因子 高甲基化 信号转导 白血病 

分 类 号：Q7[生物学—分子生物学] R733.7[医药卫生—肿瘤]