七氟烷与异氟烷对乳腺癌患者凝血功能的影响  

The effects of anaesthesia with inhaled sevoflurane or isoflurane on coagulation in patients undergoing breast cancer radical surgery

作　　者：孙建合[1] 高鲁渤[1] 李锦成[1] 李芬[1] 

机构地区：[1]天津医科大学肿瘤医院麻醉科,天津300060

出　　处：《天津医科大学学报》2007年第1期69-72,共4页Journal of Tianjin Medical University

摘　　要：目的:观察七氟烷对乳腺癌患者全血凝血功能的影响,并与异氟烷进行比较。方法:30例ASAⅠ～Ⅱ级择期行乳腺癌根治术的患者分为两组,术前用药、麻醉诱导用药均相同。麻醉维持一组用七氟烷,另一组用异氟烷。麻醉前、手术结束即刻两个时点抽血检测血栓弹性描记图、凝血4项指标。观察两组凝血功能的变化。结果:七氟烷和异氟烷麻醉手术前后凝血功能影响的比较未见统计学差异(P>0.05)。其它监测指标的比较亦未见统计学差异(P>0.05)。结论:与异氟烷麻醉相比较,七氟烷麻醉对全血凝血功能无明显影响。Objective： To investigate whether the clinical use of the sevoflurane modify the parameters of conventional coagulation and thrombelastographic tests and compare sevoflurome with isoflurane anesthesia in patients who undergo radical surgery of breast cancer. Methods： Thirty ASA Ⅰ - Ⅱ patients scheduled for elective breast radical operation were divided into two groups（n= 15 each）. Premedication and induction of anesthesia were identical. Anesthesia maintenance was provided by sevoflurane in the first group and isoflurane in the second group. Thrombelastographic tests of whole blood were performed at the pre-induction anesthesia（T0） and immediately after the surgery （T1） in both groups. In addition, conventional coagulation parameters such as PT, APTT, TT, FIB and the times of operation and anesthesia were recorded. Results： There were no significant differences in thrombelastographic coagulation index or con- ventional coagulation parameters at two time points between two groups respectively（P〉0.05）. Conclusion： In our study, there is no significant influence on conventional coagulation and thrombelastographic variables during sevoflurane anesthesia.

关 键 词：七氟烷 异氟烷 凝血功能 血栓弹性描记图 

分 类 号：R737.9[医药卫生—肿瘤] R614[医药卫生—临床医学]