氟西汀联用碳酸锂治疗抑郁症  

Fluoxetine combined with lithium carbonate in treatment of depression

作　　者：彭冬英[1] 左小云[1] 孔令军[1] 肖瑛[1] 曾兆圣[1] 朱秋根[1] 刘翔[1] 

机构地区：[1]吉安市第三人民医院,江西吉安343000

出　　处：《中国新药与临床杂志》2007年第4期289-291,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的:评价氟西汀联用碳酸锂治疗抑郁症的疗效及安全性。方法:100例符合中国精神疾病诊断分类第3版(CCMD-3)抑郁发作标准的抑郁症病人分为2组,每组各50例,分别给予氟西汀联用碳酸锂治疗(研究组)和单用氟西汀治疗(对照组),疗程均为8 wk。根据汉密尔顿抑郁量表(HAMD)减分率评定疗效,用副反应量表(TESS)评定用药的安全性,在治疗前和治疗后的wk 1,2,4,6,8末分别对2组进行检查评定。对病人随访1 a转躁狂情况。结果:研究组总有效率为94％,对照组总有效率为77％2组间,疗效比较差异有非常显著意义(P＜0．01),不良反应的发生率差异无显著意义(P＞0．05),研究组的转躁率2％低于对照组15％。结论:氟西汀联用碳酸锂治疗抑郁症可增强疗效,起效快,安全性好,转躁率低。carbonate in the treatment of depression. therapeutic effects and safety of fluoxetine combined with lithium METHODS： One hundred patients with depression were divided into two groups, the treatment group （50 patients） and the control group （50 patients）. The patients of the treatment group were given fluoxetine combined with lithium carbonate and those of the control group with fluoxetine only. The duration of treatment in both groups lasted for 8 wk individually. The clinical therapeutic effects were assessed with the Hamilton Depressive Scale （HAMD） and the clinical drug application safety presenting as adverse reactions were evaluated with the Treatment Emergent Symptom Scale （TESS）. HAMD and TESS of the two groups were assessed before and at wk 1, 2, 4, 6, 8 after treatment. RESULTS： The total rates of therapeutic effects in patients of the treatment group and control group were 94 % and 77 % respectively with significant difference （P 〈 0.01 ）. There was no significant difference rates of TESS between two groups （P 〉 0.05）. Fluoxetine combined with lithium carbonate showed much lower incidence of shifting from depression to mania episode. CONCLUSION： Fluoxetine combined with lithium carbonate possesses more effectiveness and safety in the treatment of patients with depression together with decrease of mania-switching rate.

关 键 词：抑郁症 氟西汀 碳酸锂 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R971.41[医药卫生—临床医学]