2,4,5-三羟基苯丁酮的合成研究  

Study on Catalytic Synthesis of 2,4,5-Trihydroxybutyrophenone

作　　者：唐源胜[1] 赵丽冰[1] 林杰[1] 黄志勇[1] 

机构地区：[1]广东省食品工业研究所广东省食品工业公共实验室,广东广州510308

出　　处：《广东化工》2007年第4期34-36,共3页Guangdong Chemical Industry

摘　　要：讨论了2,4,5-三羟基苯丁酮(THBP)的催化合成方法。结果表明,以1,2,4-三羟基苯为起始原料,在惰性气体保护和催化剂AlCl3的存在下,在芳香烃与水组成的二元混合溶剂中,与丁酸酐反应,经过芳香烃溶剂的后处理,可以得到2,4,5-三羟基苯丁酮(THBP),产率最高达86%,该方法的优点在于原料易得,操作条件简单,易于控制,收率稳定,产品质量高,成本低。A new method for catalytic synthesis of 2,4,5-trihydroxybutyropHenone （THBP） was described. 1,2,4-trihydroxybenzene was used as starting material, which was commercially available. By using a mixture of aromatic hydrocarbon and water as abinary solvent, reaction of 1,2,4-trihydroxybenzene with butyricanhydride was carried out in the presence of a catalyst （ZnCl2, AlCl3 or SOCl2）. 2,4,5-trihydroxybutyrophenone was obtained in yields of 80～86% with the advantages of easy control, stable yield, high product quality and low cost.

关 键 词：2 4 5-三羟基苯丁酮(THBP) 1 2 4-三羟基苯 催化合成 产品质量 惰性气体 

分 类 号：TQ224.224[化学工程—有机化工]