Hepsin和前列腺癌  

Hepsin and prostate cancer

作　　者：陈顺平（综述）[1] 王章才（审校）[1] 

机构地区：[1]皖南医学院附属弋矶山医院泌尿外科,安徽芜湖241000

出　　处：《世界肿瘤杂志》2007年第1期52-54,共3页Tumour Journal of the World

摘　　要：Hepsin是一种Ⅱ型跨膜丝氨酸蛋白酶，其过度表达于前列腺癌中并促进其发展和转移。Hepsin对前列腺癌（Pca）的诊断，预后和治疗具有重要作用，因此深入探讨Hepsin的结构，作用及与Pca的关系具有重要意义。本文对Hepsin的结构，作用及与Pca的关系作扼要综述。Hepsin is a type Ⅱ transmembrane serine protease that is highly upregulated in prostate cancer （Pca） and promotes tumor progression and metastasis. It plays an important role not only in diagnosis of Pca, but also in prognosis and treatment of Pca. Thus, to thoroughly probe the structure, function of Hepsin and its close relationship with Pca will be of vital significance. Here, we briefly review the structure, function of Hepsin and its relationship with Pca.

关 键 词：HEPSIN 前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]