乳腺癌相关糖复合物糖链研究进展  

Glycoconjugate glycan and its association with breast cancer

作　　者：孙兴权[1] 李静[1] 耿美玉[1] 管华诗[1] 

机构地区：[1]中国海洋大学海洋药物与食品研究所,山东青岛266003

出　　处：《中国药理学通报》2007年第4期425-427,共3页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)资助项目(No2003CB716400)

摘　　要：乳腺癌是妇科疾病中发病率最高的恶性肿瘤,从糖复合物糖链变化的角度来探讨乳腺癌的发病机制是当前疾病糖组学研究的热点。该文综述近年来乳腺细胞癌变过程中细胞膜及细胞外基质中糖蛋白、糖脂、蛋白聚糖等糖复合物的糖链变化情况,并对研究中存在的问题进行了探讨。Breast cancer has the highest incidence of gynecologi- cal tumors. Investigating into pathogenesis of breast cancer resuiting from the change of glycoconjugate glycan has become the hotspot in disease glycomics. The diversified situation of glyco-conjugate glycan and its association with breast cancer are reviewed and some issues are also discussed.

关 键 词：乳腺癌 糖复合物 糖链 肿瘤糖链标志物 

分 类 号：R-05[医药卫生] R329.21