失眠动物模型研究进展  

Progress in the study on insomnia animal model

作　　者：李海静[1] 高月[1] 刘萍[2] 马增春[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]中国人民解放军总医院中药房,北京100853

出　　处：《中国药理学通报》2007年第4期437-440,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30472202)

摘　　要：催眠药物是对失眠症进行对因和对症治疗的首选药物。设计和选择良好的动物模型是催眠药物从临床前基础研究过渡到临床研究的关键环节之一。该文从模型制作的不同理论根据(中医理论和西医理论)出发,对近年来催眠药物研究所用的失眠动物模型的造模机制、具体方法、优缺点及适用情况作一简要综述。Hypnotic is the choice drug which etiologically and semeiologically treats insomnia. One of the key points for the hypnotic study is to design and choose satisfactory animal models, which links the preclinical foundation research to the clinical research. In this paper, according to the different models building theories Traditional Chinese Medicine and modern medicine, the mechanisms, methods, advantages and disadvantages, applicable conditions of the insomnia animal models building were reviewed briefly.

关 键 词：失眠 动物模型 睡眠剥夺 

分 类 号：R-05[医药卫生] R338.63