PPARr2基因Pro12Ala多态性与脑梗死的关系  

Relationship Between PPARr2 Gene Pro12Ala Polymorphism and Cerebral Infarction

作　　者：黄蕾[1] 谷文萍[1] 李伟[1] 王妮妮[1] 宋晓明[1] 王玉周[1] 彭颖琼[1] 

机构地区：[1]中南大学湘雅医院神经内科,湖南长沙410008

出　　处：《实用预防医学》2007年第2期289-291,共3页Practical Preventive Medicine

基　　金：2006中南大学大学生教育计划项目;湖南省自然科学基金(02JJY3028);教外司留学回国基金(教外司留[2006]331号;湖南省卫生厅课题(B2005023)

摘　　要：目的探讨过氧化物酶体增殖体激活受体γ2(PPAR-γ2)基因Pro12Ala多态性与脑梗死的相关性。方法用聚合酶链反应-限制性片段长度多态性方法分析190例脑梗死患者和200例正常对照人群PPARγ2Pro12Ala多态,并测定总胆固醇(TC)、空腹血糖、甘油三脂(TG)、血压、体重指数(BMI)、颈动脉内中膜厚度(IMT)等。结果脑梗死组和正常对照组PPARγ2基因P/P型频率分别为0.900和0.884,P/A型频率分别为0.095和0.116,PPARγ2基因频率分布在两组间无显著性差异(P>0.05)。脑梗死组中,P/A+A/A型颈动脉IMT较P/P型显著增高(P<0.05)。结论PPARr基因Pro12Ala多态性可能不是脑梗死发病的遗传因素,但可能与动脉粥样硬化及颈动脉内中膜增厚有关。Objective To investigate the relationship between peroxisome proliferator activated receptorγ2 （PPARr2） gene Pro12Ala polymorphism and cerebral infarction in Ohangsha population, Methods Pro12Ala of PPARr2 in 190 patients with cerebral infarction and 2,00 non - cerebral infarction control subjects were analyzed by POR - RFLP and electrophoresis, and their data of TG, TO, HDL, LDL, fasting glucose, blood pressure, BMI and IMT were collected and reviewed. Results Allele frequencies of Pro12Ala mutation of PPARγ2 Pro12Ala polymophism in the cerebral infarction group were PP 0.900 and PA 0.095, and PP 0.884 and PA 0. 116 in the control group. No statistical significiant difference was found in distribution of genotype between these two groups （P 〉 0.05）. Distribution of frequencies of each genotype of Pro12Ala variant of PPAR γ2 was not significantly associated with BMI, fasting glucose, blood pressure, and lipid profiles. In the cerebral infarction group, subjects＇with PPARγ2 allele had higher carotid IMT （P〈0.05）. Conclusion The Pro12Ala mutation in PPARγ2 is not associated with cerebral infarction; but the variant of PPAR γ2 might promote the increase of carotid IMT in patients suffering from cerebral infarction.

关 键 词：脑梗死 动脉粥样硬化 过氧化物酶体增殖体激活受体γ2 基因多态性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]