急性白血病LDH及HBDH测定的临床意义  

Clinical Significance of Serum LDH and HBDH in Acute Leukemia

作　　者：曹志红[1] 祝焱[1] 彭敏源[1] 

机构地区：[1]中南大学湘雅医院检验科,湖南长沙410008

出　　处：《实用预防医学》2007年第2期489-490,共2页Practical Preventive Medicine

摘　　要：目的观察急性白血病患者血清LDH及HBDH的含量变化,探讨血清LDH和HBDH与白血病细胞变化的关系及其临床意义。方法采用速率法检测70例白血性白血病患者和24例非白血性白血病患者血清LDH和HB-DH,并与50例健康体检人作对照分析,动态观察了39例急性白血病缓解前后血清LDH和HBDH的变化。结果白血性白血病患者血清LDH和HBDH明显高于非白血性白血病患者和正常对照组(P<0.01),非白血性白血病患者血清LDH和HBDH与正常对照组差异无显著性(P>0.05),而且急性白血病缓解前后血清LDH和HBDH差异有显著性(P<0.01)。结论血清LDH和HBDH可作为急性白血病诊断、疗效、预后的一个辅助指标。Objective To detect the changes of serum LDH and HBDH, and to study the relation between serum LDH, HBDH and the cells of leukemia and its clinical significance in patients with acute leukemia. Methods Speed ratios of serum LDH and HBDH in 70 cases of leukemic leukemia, 24 cases of aleukemic leukemia and 50 cases of healthy group were assessed and analyzed. The difference of serum LDH and HBDH before and after remission were monitored. Results Serum LDH and HBDH in patients with leukemic leukemia was significantly higher than those of patients with aleukemic leukemia and healthy subjects （P〈 0.01 ）, but the levels of serum LDH and HBDH between aleukemic leukemia group and the control group showed no significant difference （P〉0.05）, and the levels of serum LDH and HBDH before and after remission were significantly different （P〈 0.01）. Conclusion Serum LDH and HBDH of acute leukemia shows positive correlation with leukemia cells , and hence serum LDH and HBDH may be used as a complementary marker in diagnosis, prognosis and evaluation of treatment efficacy in acute leukemia.

关 键 词：急性白血病 血清 LDH HBDH 临床意义 细胞变化 乳酸脱氢酶 

分 类 号：R733.7[医药卫生—肿瘤]