萘普生海藻酸钙凝胶微丸的制备及体外释药  

Preparation and in vitro release characterization of naproxen calcium alginate gel micro pills

作　　者：孙淑萍[1] 李高[1] 沈灵佳[2] 刘红[2] 周利娟[2] 

机构地区：[1]华中科技大学同济医学院药学院,湖北武汉430030 [2]湖北省医药工业研究院有限公司,湖北武汉430061

出　　处：《中国医院药学杂志》2007年第4期485-487,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备萘普生海藻酸钙凝胶微丸,并建立其释放度测定方法。方法:采用均匀设计优化处方,用分光光度法测定萘普生的含量,用体外溶出实验考察其释放效果。结果:在优化条件下制备的凝胶微丸外观好,载药量(62.2±1.8)%,在模拟胃液(SGF)中2h释放率小于3.1%,在模拟肠液(SIF)中45min释放达95%以上。结论:在优化条件下可制备外观好,载药量高的萘普生海藻酸钙凝胶微丸,体外溶出符合肠溶特征。OBJECTIVE To prepare naproxen calcium alginate gel micro pills, and determine the release of the drug. METHODS The formulation was optimized by uniform design. The concentration of naproxen in the release medium was assayed by UV-VIS spectrophotometry. The dissolution behavior of the pills was determined in vitro. RESULTS The gel beads micro pills prepared under the optimum condition were with a good appearance, and the drug loading was （62. 2±1.8） %. The drug released from the gel micro pills was less than 3. 1% in SGF during 2 hours, and more than 95% in SIF during 45 minutes. CONCLUSION The gel micro pills have a good appearance with high drug loading and the enteric release property.

关 键 词：均匀设计 萘普生 海藻酸钙 肠溶 

分 类 号：R944.9[医药卫生—药剂学] R971.1[医药卫生—药学]