低氧预适应对移植肝脏肝窦内皮细胞损伤的影响  

The Influence of HP on the Injury of Sinusoidal Endothelial Cell in Transplanted Liver

作　　者：陶立德[1] 张培建[1] 田明祥[1] 王懋莉[1] 冯敏[1] 金成[1] 

机构地区：[1]扬州大学第二临床医学院普通外科研究室,江苏扬州225001

出　　处：《实用临床医药杂志》2007年第2期39-42,共4页Journal of Clinical Medicine in Practice

基　　金：江苏省科技厅社会发展科技计划项目(BS2005038)

摘　　要：目的探讨低氧预适应对肝脏移植大鼠术后早期SEC结构和肝功能改变的影响。方法用“二袖套法”建立大鼠原位肝脏移植模型,A组:原位肝移植对照组,B组:低氧预适应组,C组:正常大鼠对照组,测定HA、ET-1、SEC显微和超微结构改变及一周存活率。结果术后B组比A组HA水平明显降低,SEC结构得到更好的保存、一周生存率显著提高(P<0.05)。结论低氧预适应可减轻SEC的损伤,避免术后的无复流及进一步的肝实质损伤,减少术后PGF的发生,提高了存活率。Objective To study the influence of hypoxia pre-conditioning on the early SEC structure and liver function in rats after transplantation. Methods To determine HA, ET-1, SEC and weekly survival rate, we use diplo-sleeve method to construct the orthotope-transplantanion model in rats, namely group A （control group of orthotope-transplantanion）, group B（group of hypoxia pre-conditioning） and group C （group of normal rats）. Result HA of group B is obviously lower than that of group A after operation, SEC structure is well conserved, and the weekly survival rate increases obviously （P 〈 0.05）. Conclusion Hypoxia pre-conditioning could relieve injury of sec, avoid no-reflow and further injury of liver. It could decrease the occurrence of PGF, thus increasing the survival rate.

关 键 词：低氧预适应 肝移植 肝窦内皮细胞 

分 类 号：R73-35[医药卫生—肿瘤]