幕上星形细胞瘤瘤周水肿MRI表现与P53蛋白的对照研究  

Correlative study between peritumoral edema on MRI and P53 protein in supratentorial astrocytic gliomas

作　　者：周东海[1] 何宁[2] 黄进[1] 张静[2] 赵志文[1] 李炳翠[1] 李刚[2] 位春萍[2] 

机构地区：[1]新疆克拉玛依市中心医院放射科,新疆克拉玛依834000 [2]兰州大学第二医院放射科,甘肃兰州730030

出　　处：《中国临床医学影像杂志》2007年第3期167-170,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:分析幕上星形细胞瘤瘤周水肿的MRI表现,探讨瘤周水肿MRI评分与肿瘤组织P53蛋白表达的相关性,揭示幕上星形细胞瘤瘤周水肿MRI表现的分子生物学基础。方法:42例经手术病理证实的幕上星形细胞瘤,包括Ⅰ级5例,Ⅱ级8例,Ⅲ级10例,Ⅳ级19例。对其术前MRI图像瘤周水肿程度进行评分,术后组织切片进行P53蛋白免疫组织化学染色。分析肿瘤细胞P53蛋白的表达情况,与瘤周水肿程度对照并做相关性分析。结果:42例幕上星形细胞瘤P53阳性细胞率平均值为48.35%±23.44%,范围10%～85%。随着瘤周水肿MRI评分的增高,P53阳性细胞率亦随之增加(P<0.05)。结论:幕上星形细胞瘤瘤周水肿MRI表现反映了肿瘤组织P53蛋白的表达程度。MRI可以快捷、无创伤性地评价幕上星形细胞瘤P53蛋白的表达程度,可进一步估计其分子生物学行为及判断预后。Objective： To analyse the peritumoral edema of supratentorial astrocytic gliomas on MRI, to investigate the correlation between the MRI scores of peritumoral edema degree and P53 protein. To reveal the molecular hiological foundation of MRI of peritumoral edema in supratentorial astrocytic gliomas. Methods： We analyzed MR features of 42 cases peritumoral edema in the supratentorial astrocytic gliomas verified hy surgery and pathology, including 5 grade Ⅰ, 8 grade Ⅱ, 10 grade Ⅲ and 19 grade Ⅳ tumors. All the cases were divided into 4 groups according to the scores of peritumoral edema. Histopathological slides underwent P53 protein immunohistochemical staining. The expressions of P53 protein were analyzed and compared with their scores of peritumoral edema. The data were correlatively studied. Results： In 42 cases, the positive expression rate of P53 protein was 10% to 85% with an average of 48.35%±23.44%. The positive expression rate of P53 protein increased with the increasing of peritumoral edema scores（P〈0.05）. Conclusion： The peritumoral edema on MRI in supratentorial astrocytic gliomas can reflect the positive expression rate of P53 protein. MRI may prove to be a valuable means in estimating the expression of P53 protein in supratentorial astrocytic gliomas quickly and noninvasively, and further predicting the molecular biological behavior of supratentorial astrocytic gliomas and judging the prognosis.

关 键 词：脑肿瘤 星形细胞瘤 蛋白质P53 磁共振成像 

分 类 号：R739.41[医药卫生—肿瘤] R730.264[医药卫生—临床医学]