2000至2004年新疆维吾尔自治区莱姆病的监测  

Surveillance of Lyme Disease in Xinjiang Uygur Autonomous Region During 2000-2004

作　　者：谭毓绘[1] 刘勇[2] 孙荷[2] 于鲁海[3] 龙江[1] 牛晓珊[1] 曼古努[1] 莫合塔尔[1] 朱沂[1] 吴玛 

机构地区：[1]新疆维吾尔自治区人民医院神经内科,830021 [2]新疆维吾尔自治区人民医院儿科研究所,830021 [3]新疆维吾尔自治区人民医院药学研究所,830001 [4]新疆博州州医院,830021

出　　处：《中国临床神经科学》2007年第2期158-161,共4页Chinese Journal of Clinical Neurosciences

基　　金：新疆维吾尔自治区人民医院院内项目(007)

摘　　要：目的:监测莱姆病(LD)在新疆地区的流行情况与特征,为LD的防治提供决策依据。方法:2000至2004年采用间接免疫荧光抗体法(IFA)、蛋白印迹法(WB),对业已证实的新疆自然疫源地区2167人份的血清标本进行抗LD螺旋体抗体(IgM、IgG)检测;采用IFA、WB、ELISA试验对来自21个县、市的门诊与住院患者,随机抽样1443人份血清标本进行抗LD螺旋体抗体(IgM、IgG)检测作对照;共计3610份血清标本。结果:自然疫源地2167人份血清中IFA:IgM阳性数546人、IgG阳性数223人、总阳性数769人,总阳性率为35.49%。其中471人份血清同时作WB法,其IgM、IgG阳性数均为28人,阳性率为13.49%,与对照组总阳性率20.99%比,差异有统计学意义(P<0.01)。结论:新疆自治区LD自然疫源地平均感染率明显高于国内(1.5%和8.06%)水平,各年度的抗体水平呈递增趋势,应该加强对新疆LD的监测与防治。Aim： To survey the prevailing condition and characteristic of Lyme disease in Xinjiang Uygur Autonomous Region,to provide the evidence for Lyme disease control. Methods： Over a 5-year period （2000-2004）,the serum antibodies measurement of against Lyme borreliosis with the serological tests： a sensitive IFA as the first step, followed by WB（IgM and IgG）in 2 167 people＇s serum specimen of Xinjiang natural foci compared with random sampling 1 443 people from out-patient clinic and hospital patients in country and city. Results： The total positive rates for serum antibodies are 35.49% in natural foci; and the total positive rates for serum antibodies are 20.99% in contrast team. There is marked difference between the two teams, P 〈 0.01. Conclusion： The infection rate of Lyme disease in Xinjiang presented the higher level, exceeded national level （1.5% and 8.06%）. Thus it should enhance the monitoring and prevention and cure for Lyme disease.

关 键 词：莱姆病抗体 间接免疫荧光抗体法 蛋白印迹法 酶联免疫吸附试验 

分 类 号：R742[医药卫生—神经病学与精神病学] R514.4[医药卫生—临床医学]