血红素加氧酶系统在神经系统疾病中变化的研究进展  

The Retrospect and Prospect of Heme Oxygenase in Nervous System Disease

作　　者：郭筱华[1] 赵忠新[1] 

机构地区：[1]第二军医大学附属长征医院神经内科,200003

出　　处：《中国临床神经科学》2007年第2期212-216,共5页Chinese Journal of Clinical Neurosciences

摘　　要：血红素加氧酶(HO)在神经系统广泛分布,其反应产物即铁离子、一氧化碳和胆色素都是生物活性分子,对细胞的生存和增殖有广泛的生物学作用。同工酶HO-1和HO-2不同的分子特性和脑内不同的调控特点决定了两者神经功能的差别。HO-2在生理情况下大量表达维持脑的正常功能;而HO-1与神经系统疾病密切相关。大量研究表明HO-1的上调表达对氧化应激引起的神经系统疾病有保护作用,另一方面使铁离子病理性沉积促进了神经系统变性疾病的发生。Heme oxygenase have been found to distribute widely in nervous system. The products of the heme oxygenase reaction ,free ferrous iron, carbon monoxide and biliverdin/bilirubin, are all biologically active molecules that may exert profound effects on cell survival and proliferation. Two HO isoenzymes, HO-1 and HO-2, have different effects with different molecule characteristic and mechanism of regulation. In physiological condition, HO-2 is abundantly and fairly ubiquitously expressed and may exert neuroprotective effects. Unlike HO-2, evidence indicates induction of the HO-1 gene in various CNS disease involving oxidative stress is usually beneficial. Also, HO-1 hyperactivity may contribute to the pathological iron deposition and exacerbate neurodegeneration.

关 键 词：血红素加氧酶 一氧化碳 铁离子 胆红素/胆绿素 神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学] Q189[医药卫生—临床医学]