后Tenon’s注射曲安奈德治疗弥漫性糖尿病性黄斑水肿  

Posterior Sub-Tenon's triamcinolone acetonide injection for the treatment of diffuse diabetic macular edema

作　　者：李国星[1] 林冰[1] 李英姿[1] 宋慧洋[1] 方海珍[1] 刘晓玲[1] 

机构地区：[1]温州医学院附属眼视光医院,浙江温州325027

出　　处：《眼视光学杂志》2007年第2期100-102,共3页Chinese Journal of Optometry & Ophthalmology

基　　金：浙江省医药卫生重点科技项目计划(2004B159)

摘　　要：目的评价后Tenon’s注射曲安奈德治疗弥漫性糖尿病性黄斑水肿的疗效与安全性。方法对弥漫性糖尿病性黄斑水肿16例(27眼)行后Tenon’s注射曲安奈德40mg,于术前和术后不同时间点检查视力、眼压、光学相干断层扫描(optical coberence tamography,OCT)、眼底荧光造影等项目。结果术后平均视力明显改善,术前平均视力是4.25±0.39,术后2周、1个月、2个月、4个月平均视力分别为4.40±0.34、4.54±0.33、4.61±0.28、4.58±0.27,术前和术后各时间点平均视力相比均提高,差异有显著性(P<0.05)。术前黄斑中心凹1mm直径平均厚度、黄斑3.45mm直径平均体积及6mm直径平均体积分别是(411.58±22.08)μm、(3.84±0.13)mm3和(10.51±0.35)mm3,术后1个月分别是(299.33±17.94)μm、(3.21±0.12)mm3和(9.26±0.31)mm3,2个月分别是(259.13±13.74)μm、(2.98±0.91)mm3和(9.04±0.28)mm3,4个月分别是(292.92±25.61)μm、(3.13±0.16)mm3和(9.19±0.34)mm3,术前和术后各时间点相比有下降趋势,且差异均有显著性(P<0.05)。术后2个月平均眼压升高,和术前相比差异有显著性。所有患者除眼压升高外无其他并发症发生。结论后Tenon’s注射曲安奈德是一种治疗糖尿病性黄斑水肿的有效、安全手段。Objective To study the effect of a Posterior Sub-Tenon＇s triamcinolone acetonide （TA） injection as a treatment for diffuse diabetic macular edema （DME）.Methods A prospective pilot study of patients who had received a posterior Sub-Tenon＇s injection of 40 mg TA for treatment of DME was done. Sixteen eyes of 27 patients were treated. All eyes were examined before treatment and throughout the follow-up period by testing visual acuity, fluorescein angiography （FA）, optical coherence topography （OCT） and intraocular pressure. Results Mean visual acuity improwd significantly. Average preoperative visual acuity was 4.25 ± 0.39 and postoperative visual acuity was 4.40±0.34, 4.54±0.33, 4.61 ±0.28, 4.58 ± 0.27 at two weeks, one month, two months and four months, respectively. The average central retinal thickness and macular volume had been significantly reduced as measured by OCT. At the same time, however, the mean intraocular pressure was elevated at 2 months after TA injection. No other complications were observed. Conclusion Posterior Sub-Tenon＇s injection of TA may be useful for reducing diffuse diabetic macular edema.

关 键 词：糖尿病视网膜病变/药物治疗 后Tenon’s注射 曲安奈德 黄斑水肿 

分 类 号：R774.5[医药卫生—眼科] R771.3[医药卫生—临床医学]