注射用头孢哌酮钠-舒巴坦钠与四种输液的配伍稳定性  

Stability of Cefoperazone Sodium and Sulbactam Sodium for Injection in four Infusion solutions

作　　者：王艳[1] 梁卉[1] 谭爱萍[1] 潘明臣[1] 赵恕[1] 汤新强[1] 徐奇玮[2] 

机构地区：[1]大连医科大学第一临床学院药局,辽宁大连116011 [2]大连医科大学药物分析教研室,辽宁大连116027

出　　处：《大连医科大学学报》2007年第2期115-117,138,共4页Journal of Dalian Medical University

摘　　要：[目的]考察注射用头孢哌酮钠-舒巴坦钠在0.9%氯化钠注射液、5%葡萄糖注射液、5%葡萄糖氯化钠注射液、乳酸钠林格注射液四种输液中的配伍稳定性。[方法]将注射用头孢哌酮钠-舒巴坦钠分别与上述4种输液进行配伍,在0-6 h内测定pH值、微粒变化、细菌内毒素含量及含量变化。[结果]分别与上述四种输液配伍后,每毫升中粒径分别≥10μm和≥25μm以上的微粒数均符合中国药典（2005年版）规定,小粒径的微粒数有明显增加;细菌内毒素含量：0 h及6 h均〈3.0 EU.mL^-1,且随放置时间的增长有明显增加;注射用头孢哌酮钠-舒巴坦钠与5%葡萄糖氯化钠注射液配伍后含量下降约10%,而与其他3种输液配伍后含量下降不超过5%。[结论]注射用头孢哌酮钠-舒巴坦钠可与0.9%氯化钠注射液、5%葡萄糖注射液、乳酸钠林格注射液配伍使用,但不能与5%葡萄糖氯化钠注射液配伍使用;低浓度（5 mg.mL^-1 L）在0-6 h内含量没有明显变化,稳定性较好。[ Objective] To observe the stability of Cefoperazone Sodium and Sulbactam Sodium for Injection in 0.9% Sodium Chloride Injection, 5% Glucose Injection, 5% Glucose and Sodium Chloride Injection, Sodium Lactate Ringer＇s Injection. [ Methods] The pH value, particles, content of bacterial endotoxin, content of injection were measured for 0 - 6 h. [ Result ] The numbers of the particle （ ≥25 μm and ≥10 μm） measured up to standard, but there was significantly increased level in mini - particle （ 〈 10 μm）. The content of bacterial endotoxin was less than 3.0 EU · mL^-1 for 0 h,6 h and remarkable increased along with the time of placement. The content of Cefoperazone Sodium and Sulbactam Sodium for Injection decreased 10% in 5% Glucose and Sodium Chloride Injection, but with other three injections, the content decreased no more than 5%. [ Conclusion] Cefoperazone Sodium and Sulbactam Sodium for Injection was unstable in 5% Glucose and Sodium Chloride Injection, but should be used in 0.9% Sodium Chloride Injection, 5% Glucose Injection, Sodium Lactate Ringer＇s Injection.

关 键 词：注射用头孢哌酮钠-舒巴坦钠 稳定性 微粒 细菌内毒素 含量测定 

分 类 号：R944[医药卫生—药剂学]