阿魏酸钠对溃疡性结肠炎患者氧化损伤和花生四烯酸代谢的影响  

Effects of sodium ferulate on the oxidative damage and arachidonic acid metabolism in patients with ulcerative colitis

作　　者：方春华[1] 刘少平[1] 董元英[1] 董卫国[2] 余立群[1] 何仁胜[1] 

机构地区：[1]武汉大学医学院湖北黄石市中心医院消化内科,湖北黄石435000 [2]武汉大学人民医院消化内科

出　　处：《中国医师杂志》2007年第4期489-491,共3页Journal of Chinese Physician

摘　　要：目的探讨阿魏酸钠对溃疡性结肠炎（UC）患者氧化损伤与花生四烯酸代谢的影响及其临床治疗意义。方法检测38例溃疡性结肠炎患者和30例健康对照者的血MDA，LPO，SOD，NO，PGE2和TXB2的水平变化，同时检测结肠髓过氧化物酶（MPO）活性，评价UC患者病情活动指数（CAI）与内镜分级。结果UC患者组血MDA，LPO，NO，PGE2，TXB2水平及结肠组织MPO活性显著高于正常对照组，血SOD活性显著低于正常对照组（P〈0．01），阿魏酸钠（SF）治疗后UC患者组各检测指标异常得到显著改善，同时CAI评分与内镜分级亦显著得到改善（P〈0．01）。结论阿魏酸钠显著缓解UC患者氧化损伤，抑制花生四烯酸代谢过度．减轻结肠炎症反应与损伤，有一定临床治疗价值。Objective To investigate the effects of sodium ferulate on the oxidative damage and arachidonic acid metabolism in patients with ulcerative colitis（UC） and its clinical significance. Methods In 38 patients with UC and 30 healthy people, prostaglandin E2 （PGE2） , thromboxane B2 （TXB2） , Malondiadchyde （MDA）, Lipid superoxide （LPO）, activity of superoxide dismutase （SOD） in blood and activity of myeloperoxidase （MPO） in colon were detected by corresponding kits while CAI grade and endoscope grade were evaluated. Result Compared with the control group, levels of MDA, LPO, NO, PGE2,TXB2 in blood and activity of MPO in colon of patients with UC group were significantly increased while activity of SOD in blood was significantly decreased （ P 〈 0. 01 ） ; After sodium ferulate injection treatment, all the abnormal indexes in patients with UC group were markedly ameliorated （ P 〈 0. 01 ）. Conclusion Sodium ferulate can significantly resist oxidative damage and restrain arachidonic acid metabolism in UC, therefore relieve the inflammatory reaction and injury in colon. It has therapeutical value in treating UC.

关 键 词：阿魏属 结肠炎 溃疡性/治疗 花生四烯酸 氧化还原 

分 类 号：R57[医药卫生—消化系统]