中国人纤维蛋白原β链基因-148C/T、-455G/A多态性与脑梗死关系的Meta分析  

Meta analysis on relationship between beta-fibrinogen gene -148C/T and -455G/A polymorphisms and susceptibility of cerebral infarction in chinese people

作　　者：陈筱潮[1] 徐明彤[2] 韩春丽[1] 陈维清[3] 伍卫[1] 

机构地区：[1]中山大学附属第五医院内科,珠海519000 [2]中山大学附属第二医院内分泌内科,广州510120 [3]中山大学公共卫生学院,广州510080

出　　处：《中华神经医学杂志》2007年第4期357-361,共5页Chinese Journal of Neuromedicine

基　　金：广东省科技发展计划资助项目(2005B33701022;2006B36007005)

摘　　要：目的对中国人纤维蛋白原β链基因-148C/T、-455G/A多态性与脑梗死相关性的研究进行Meta分析。方法通过文献检索收集自1994年1月1日至2005年12月30日发表的中国人纤维蛋白原β链基因-148C/T、-455G/A多态性与脑梗死关系的病例-对照研究,剔除不符合要求的文献,以漏斗图检验入选文献的发表偏倚,并根据各入。选文献结果的同质性检验结果进行数据合并,计算总OR值,Meta分析采用Review Manager 4.2版统计软件。结果共9篇关于-148C/T多态性和11篇关于-455G/A多态性的文献符合条件纳入研究,入选文献无明显发表偏倚,各文献同质性检验显示有关-148C/T(x^2=16.42,P=0.04)和-455G/A(x^2=29.89,P=0.0009)多态性文献间均存在显著异质性。数据合并结果显示-148C/T多态性位点(C/T+T/T)比C/C发生脑梗死的OR值为1.35,95%CI为1.02～1.78(P=0.03),-455G/A多态性位点(G/A+A/A)比G/G发生脑梗死的OR值为1.38,95%CI为1.03～1.85(P=0.03)。结论纤维蛋白原β链基因-148C/T、-455G/A多态性与中国人脑梗死易感性相关,-148T、-455A等位基因可能是脑梗死的遗传危险因素。Objective To evaluate the correlation between the β-fibrinogen gene -148C/T and - 455G/A polymorphisms and cerebral infarction in Chinese population by means of Meta analysis. Methods Genetic association studies evaluating the β-fibrinogen gene -148C/T and -455G/A polymorphisms and cerebral infarction involving Chinese population published from Jan. 1, 1994 to Dec. 30, 2005 were collected from databases of PubMed, EMBASE, and CNKI. The literatures were abstracted based on the defined selection criteria by two independent investigators. Publication bias was tested by funnel plot and the odd ratio （OR） of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Review Manager （Version 4.2） was used for Meta analysis. Results Nine studies involving -148C/T polymorphism and 11 studies involving -455 G/A polymorphism met the selection criteria. There was no significant publication bias in selected studies, heterogeneity test of reviewed studies showed that there were significant statistic differences among the OR of studies involving -148C/T （χ^2=-16.42, P=0.04） and individual studies involving -455G/A （12=29.89, P=0.0009）. The combined OR of susceptibility to cerebral infarction in -148T allele carriers compared to -148C/C wild homozygotes was 1.35 （95% CI 1.02-1.78, P=0.03） and in -455A allele carriers compared to the -455G/G wild homozygotes was 1.38 （95%CI 1.03-1.85, P=0.03）. Conclusion β-fibrinogen gene -148C/T and -455G/A polymorphisms might contribute to susceptibility of cerebral infarction in Chinese population; the allele -148T and -455A are genetic risk factors for cerebral infarction.

关 键 词：纤维蛋白原β链 脑梗死 基因多态性 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]