血清VEGF、VEGF C和uPAR水平与口腔鳞状细胞癌的关系  

Serum Levels of VEGF,VEGF C and uPAR in Patients withOral Squamous Cell Carcinoma

作　　者：禹雪梅[1] 刘晓勇[1] 王雅杰[2] 丁利[1] 

机构地区：[1]首都医科大学附属北京口腔医院病理科 [2]首都医科大学附属北京天坛医院实验诊断中心

出　　处：《首都医科大学学报》2007年第2期158-161,共4页Journal of Capital Medical University

基　　金：首都医学发展科研基金(2002-2051)资助项目

摘　　要：目的通过检测口腔鳞状细胞癌(OSCC)患者血清中血管内皮生长因子(VEGF)、血管内皮生长因子C(VEGF C)和尿激酶型纤溶酶原激活剂受体(uPAR)的水平,探讨其与OSCC病理学改变和淋巴结转移的关系。方法用酶联免疫吸附分析法检测91例OSCC患者和50例健康人血清中VEGF、VEGF C和uPAR的水平。结果OSCC患者血清VEGF、VEGF C、uPAR含量显著高于健康对照组,差异有统计学意义(P<0.01),血清VEGF、VEGF C和uPAR水平与口腔癌患者的病理分级、浸润方式和淋巴结转移无显著相关性。结论血清VEGF、VEGF C和uPAR水平可为监测口腔癌的发生发展提供实验依据,但对判断OSCC的转移无显著意义。Objective The serum levels of VEGF, VEGF C and uPAR in patients with oral squamous cell carcinoma（OSCC） were determined to study the relationship between VEGF, VEGF C and uPAR serum levels and pathological parameters or lymphatic metastasis in OSCC. Methods Serum levels of VEGF, VEGF C and uPAR were measured with quantitative enzyme-linked immunosorbent assay in 91 patients with OSCC and in 50 healthy individuals as control group. Results Significantly elevated levels of VEGF, VEGF C and uPAR were observed in OSCC compared with control group. No statistically significant correlation could be found between the serum levels and histological grading, infiltrative mode or nodal status in OSCC. Conclusion Serum determinations of VEGF, VEGF C and uPAR may provide laboratory data for monitoring the occurrence and development of OSCC, but have no significance in predicting lymphatic metastasis.

关 键 词：口腔癌 血管内皮生长因子 血管内皮生长因子C 尿激酶型纤溶酶原激活剂受体 

分 类 号：R739.81[医药卫生—肿瘤]