MMP-2和TIMP-2在胃癌中的表达与临床意义  

Expression and clinical implication of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in gastric carcinoma.

作　　者：王菊岩[1] 刘舒颖[1] 刘涛[1] 

机构地区：[1]广东医学院附属医院消化内科内镜中心,广东湛江524001

出　　处：《中国热带医学》2007年第5期687-688,共2页China Tropical Medicine

摘　　要：目的探讨胃癌中基质金属蛋白酶2(MMP-2)、金属蛋白酶组织抑制因子2(TIMP-2)的表达及其与肿瘤分化程度和淋巴结转移的关系。方法利用ABC免疫组化技术观察60例胃癌(高分化鳞癌40例,低分化鳞癌20例,其中28例淋巴结转移)。结果MMP-2与TIMP-2表达于癌细胞胞浆中,MMP-2表达阳性率为45%,在低分化胃癌中的表达高于高分化者(P=0.0358),在有淋巴结转移中的表达明显高于无淋巴结转移(P=0.0005)。TIMP-2表达阳性率为40%,在高分化或无淋巴结转移的胃癌中的表达高于低分化(P=0.0234)或有淋巴结转移者(P=0.0414)。结论胃癌中MMP-2和TIMP-2表达与其分化程度及淋巴结转移有关。Objective To investigate the expression of matrix metalloproteinase 2 （MMP- 2）, tissue inhibitor of metallopro- teinase 2（TIMP - 2） in gastric carcinoma and its clinical implication in expressions and tumor differentiation and lymph node metastasis. Methods The expressions of MMP- 2, TIMP- 2 were observed by ABC imunohistochemiccal technique in 60 gastric carcinoma patients including 28 gastric carcinoma with lymph node metastases, among them there were 40 highly differentiated and 20 poorly differentiated ones. Results MMP- 2 and TIMP- 2 were localized within cytoplasm of tumor cells. MMP- 2 expressive rate was 45 %, and expression in poorly differentiated tumors was higher than that in highly differentiated ones （ P = 0.0358）, the higher ex- pression of MMP- 2, higher rate of lymph node metastasis （ P =0.0005）. The expressions rate of TIMP- 2 was 40%, and the expression in well differentiated gastric carcinoma or without lymph node metastasis were higher than those in poorly differentiated ones （ P = 0.0234） or with positive metastasis （ P = 0.0414）. Conclusion Expressions of MMP - 2 and TIMP - 2 is associated with the differentiation and lymph node metastasis in gastric carcinoma patients.

关 键 词：胃癌 基质金属蛋白酶2 金属蛋白酶组织抑制因子2 

分 类 号：R735.2[医药卫生—肿瘤]