p53及nm23在胃癌中的表达及其与淋巴结转移的关系  

Expression p53 and nm23 and its correlation with lymph node metastasis in human gastric cancer.

作　　者：赵茜[1] 区穗芳[1] 谢秀琴[1] 

机构地区：[1]广东药学院附属第一医院,广东广州510080

出　　处：《中国热带医学》2007年第5期689-690,共2页China Tropical Medicine

摘　　要：目的探讨p53及nm23在胃癌中的表达及其与淋巴结转移的关系。方法应用免疫组化S-P法对100例胃癌手术根治标本进行p53和nm23检测。结果p53和nm23阳性表达率分别为61%和60%。p53过表达与胃癌淋巴结转移关系密切(P<0.01);nm23低表达与胃癌侵袭程度、淋巴结转移有明显相关性(P<0.01)。p53过表达和nm23低表达在胃癌淋巴结转移中可能起协同作用。结论联合检测p53蛋白及nm23基因表达状况可作为临床预测胃癌淋巴结转移的一项参考指标。Objective To investigate the expression of p53 and nm23 in gastric cancer patients and its correlation with lymph node metastasis. Methods S-P immunohistochemical method was used to detect the expression of p53 and nm23 in 100 gastric cancer patients after surgical treatment. Results The expression rate of p53 and nm23 in 100 cases were 61% and 60% respectively. A significant correlation was found between p53 overexpression and the lymph node metastasis （ P 〈 0.01 ）. A significant correlation was found between low - expression of nm23 and the depth of cancer invasion and the lymph node metastasis （ P 〈 0.01 ）. The p53 overexpression and rim23 Low- expression to the lymph node metastasis might be jointly acted. Condusion The combined detection of expression of p53 protein and nm23 can probably be used as a indicator for predicting lymphatic metastasis of gastric cancer.

关 键 词：胃癌 P53 NM23 淋巴结转移 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]