过量氟对兔髁状软骨细胞外基质胶原和蛋白多糖代谢的影响  

Effects of overdose fluoride on metabolism of extracellular matrix collagen and proteoglycan in condylar cartilage

作　　者：倪雪岩[1,2] 蔡家骏[1,2] 侯立中 常淑芳[1,2] 张连春 

机构地区：[1]白求恩医科大学口腔医学院 [2]白求恩医科大学地方病研究所

出　　处：《中华口腔医学杂志》1997年第1期52-54,共3页Chinese Journal of Stomatology

摘　　要：为了探讨过量氟对髁状软骨和下颌骨发育的影响，通过生物化学检测、光镜观察和Ｘ线摄影测量，从细胞外基质代谢的角度观察了有关的指标。结果显示氟中毒家兔髁状软骨胶原含量明显降低（Ｐ＜０．０１），蛋白多糖含量明显升高（Ｐ＜０．０１）；髁状软骨生发层变薄，成熟层细胞大量增生，下颌支长度明显变短（Ｐ＜０．０１）。本研究结果表明，过量氟可使髁突和下颌支生长发育受到损害。The study was conducted to evaluate the effects of chronic fluorosis on the metabolism of extracellular matrix in the development of rabbit condylar cartilage using the technique of pathology,biochemistry and radiographs.The results demonstrated that collagen content of condylar cartilage and the bone under condylar cartilage decreased( P <0.01),and the proteoglycar contents increased signficantly during the process of fluorosis ( P <0.01). The chondroprogenitor was obviously thin,and the cells of maturation zone increased in number.All the results indicated that overdose of fluoride retarded the growth of the condyle and ramus of the mandible.

关 键 词：氟中毒 下颌骨 蛋白多糖 下颌骨髁突 

分 类 号：R780.2[医药卫生—口腔医学] R595.9[医药卫生—临床医学]